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An excess of free radicals causes oxidative stress, an unstable cellular environment that can result from exposure to alcohol, medications, poor nutrition, trauma, cold, toxins, and overexercise. Free radicals and other reactive oxygen species (ROS) form when cells encounter oxidizing agents or ionizing radiation. ROS can damage DNA, an early step in carcinogenesis; damage to other biomolecules leads to atherosclerosis, cerebral and heart ischemia-reperfusion injury, rheumatoid arthritis, inflammation, diabetes, aging, neurodegenerative diseases, and other disorders. Merck offers antibodies for Oxidative Stress research, to targets such as: NOS, eNOS, Perioredoxin, Thioredoxin, RAGE, SOD, and many more.