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176901 Anthrax Lethal Factor Protease Inhibitor, In-2-LF - Calbiochem

176901
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₈₁H₁₅₀N₄₂O₁₇

Products

Catalogue NumberPackaging Qty/Pack
176901-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable N-acetylated, C-hydroxamate derivative of a 14-mer peptide designed from the MEK-2 template that acts as a competitive inhibitor of Anthrax lethal factor (LF) metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Protects against Anthrax toxin induced cytotoxicity in RAW264.7 and J772.A1 cells.
Catalogue Number176901
Brand Family Calbiochem®
SynonymsAnthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
References
ReferencesPeinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
Tonello, F., et. al. 2002. Nature 418, 386.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₈₁H₁₅₀N₄₂O₁₇
Chemical formulaC₈₁H₁₅₀N₄₂O₁₇
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Targetanthrax LF metalloprotease
Primary Target K<sub>i</sub>1 nM against Anthrax lethal factor (LF) metalloprotease
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Anthrax Lethal Factor Protease Inhibitor, In-2-LF - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Anthrax Lethal Factor Protease Inhibitor, In-2-LF - Calbiochem Certificates of Analysis

TitleLot Number
176901

References

Reference overview
Peinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
Tonello, F., et. al. 2002. Nature 418, 386.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-April-2008 RFH
SynonymsAnthrax LF Protease Inhibitor, Bacillus anthracis LF Protease Inhibitor, In-2-LF
DescriptionA cell-permeable derivative of a 14-mer peptide that is based on the MEK-2 template and acts as a competitive inhibitor of Anthrax lethal factor metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Exhibits protective effects against Anthrax toxin-induced cytotoxicity in RAW264.7 and J772.A1 cells. Reported to competitively inhibit furin (Ki = 49 nM.
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₈₁H₁₅₀N₄₂O₁₇
Peptide SequenceAc-Gly-Tyr-βAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml), 5% Acetic Acid (5 mg/ml), or H₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPeinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601.
Tonello, F., et. al. 2002. Nature 418, 386.