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189405 Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem

189405
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₁H₁₈F₃N₅O879127-16-9

Products

Catalogue NumberPackaging Qty/Pack
189405-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable 2,4-dianilinopyrimidine compound that acts as an ATP-competitive, potent, but non-selective inhibitor of Aurora A (IC50 = 42 nM). At higher concentrations, also inhibits the activities of other kinases, such as Lck, Bmx, IGF-1R, and Syk (IC50 = 131, 386, 591, and 887 nM, respectively).
Catalogue Number189405
Brand Family Calbiochem®
SynonymsCyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide, Aurora Kinase Inhibitor III
References
ReferencesZhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182.
Product Information
CAS number879127-16-9
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₁H₁₈F₃N₅O
Chemical formulaC₂₁H₁₈F₃N₅O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAurora Kinase A
Primary Target IC<sub>50</sub>42 nM against Aurora A; 131, 386, 591, and 887 nM, against Lck, Bmx, IGF-1R, and Syk , respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem Certificates of Analysis

TitleLot Number
189405

References

Reference overview
Zhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-December-2008 JSW
SynonymsCyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide, Aurora Kinase Inhibitor III
DescriptionA cell-permeable 2,4-dianilinopyrimidine compound that acts as an ATP-competitive, potent, but non-selective inhibitor of Aurora A (IC50 = 42 nM). At higher concentrations, also inhibits the activities of other kinases, such as Lck, Bmx, IGF-1R, and Syk (IC50 = 131, 386, 591, and 887 nM, respectively).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number879127-16-9
Chemical formulaC₂₁H₁₈F₃N₅O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml) or Ethanol (20 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesZhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182.