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197226 BCRP Inhbitor - Calbiochem

The BCRP Inhbitor controls the biological activity of BCRP. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

BCRP Inhbitor - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide

197226
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₂H₁₉N₃O₅

Products

Catalogue NumberPackaging Qty/Pack
197226-10MG Glass bottle 10 mg
Description
OverviewA non-tetrahydroisoquinoline BCRP specific inhibitor based on the anthranilic acid scaffold, that displays an IC50 of 1.39 µM in a Hoechst 33343 assay in stably transfected MDCK BCRP cells, which is ˜50-fold more potent than novobiocin (IC50 = 65 µM), and shows no effect towards other ATP binding cassette (ABC) transporters P-gp and MRP1 at up to a concentration of 10 µM. It is shown to be an allosteric inhibitor in enzyme kinetics assays in the presence of BCRP specific substrates pheophorbide A and imitanib, and does not lead to a decrease in cell viability up to a concentration of 10 µM.
Catalogue Number197226
Brand Family Calbiochem®
SynonymsN-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide
References
ReferencesPick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.
Product Information
FormOff-white solid
Hill FormulaC₂₂H₁₉N₃O₅
Chemical formulaC₂₂H₁₉N₃O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

BCRP Inhbitor - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

BCRP Inhbitor - Calbiochem Certificates of Analysis

TitleLot Number
197226

References

Reference overview
Pick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-February-2011 RFH
SynonymsN-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide
DescriptionA non-tetrahydroisoquinoline BCRP specific inhibitor based on the anthranilic acid scaffold, that displays an IC50 of 1.39 µM in a Hoechst 33343 assay in stably transfected MDCK BCRP cells, which is ˜50-fold more potent than novobiocin (IC50 = 65 µM), and shows no effect towards other ATP binding cassette (ABC) transporters P-gp and MRP1 at up to a concentration of 10 µM. It is shown to be an allosteric inhibitor in enzyme kinetics assays in the presence of BCRP specific substrates pheophorbide A and imitanib, and does not lead to a decrease in cell viability up to a concentration of 10 µM.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₁₉N₃O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.