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481417 CRAC Channel Inhibitor IV, EVP4593 - Calbiochem

481417
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₂H₂₀N₄O

Products

Catalogue NumberPackaging Qty/Pack
481417-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable quinazoline derivative that blocks PMA/PHA-induced NF-κB activation in Jurkat cells (IC50 = 11 nM), but has no effect on PKC kinase, and exhibits an anti-inflammatory effect on carrageenin-induced paw edema in rats (1 mg/kg, i.p.). In addition, it is shown to inhibit the store-operated calcium entry (SOC) pathway possibly by targeting TRPC1 containing heteromeric channels in Huntington Disease (HD) neurons (SK-N-SH cells transfected with mutant Huntingtin Htt-138Q) at 300 nM. It displays neuroprotective effects in YAC128 MSN mice neurons from glutamate toxicity dose-dependently from 30 nM to 3 µM, which is consistent with TRPC1 knockdown effects, and attenuates the progressive decline in the climbing speed of the HD Drosophila, dose-dependently from 100 µM to 400 µM.
Catalogue Number481417
Brand Family Calbiochem®
SynonymsN4-(4-phenoxyphenethyl)quinazoline-4,6-diamine, SOC Inhibitor
References
ReferencesWu, J., et al. 2011. Chem Biol. 18, 777.
Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 3869.
Product Information
FormYellow powder
Hill FormulaC₂₂H₂₀N₄O
Chemical formulaC₂₂H₂₀N₄O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

CRAC Channel Inhibitor IV, EVP4593 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

CRAC Channel Inhibitor IV, EVP4593 - Calbiochem Certificates of Analysis

TitleLot Number
481417

References

Reference overview
Wu, J., et al. 2011. Chem Biol. 18, 777.
Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 3869.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-February-2013 JSW
SynonymsN4-(4-phenoxyphenethyl)quinazoline-4,6-diamine, SOC Inhibitor
DescriptionA cell-permeable quinazoline derivative that blocks PMA/PHA-induced NF-κB activation in Jurkat cells (IC50 = 11 nM), but has no effect on PKC kinase, and exhibits an anti-inflammatory effect on carrageenin-induced paw edema in rats (1 mg/kg, i.p.). In addition, it is shown to inhibit the store-operated calcium entry (SOC) pathway possibly by targeting TRPC1 containing heteromeric channels in Huntington Disease (HD) neurons (SK-N-SH cells transfected with mutant Huntingtin Htt-138Q) at 300 nM. It displays neuroprotective effects in YAC128 MSN mice neurons from glutamate toxicity dose-dependently from 30 nM to 3 µM, which is consistent with TRPC1 knockdown effects, and attenuates the progressive decline in the climbing speed of the HD Drosophila, dose-dependently from 100 µM to 400 µM.
FormYellow powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₂₀N₄O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml; clear, yellow solution)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesWu, J., et al. 2011. Chem Biol. 18, 777.
Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 3869.