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264151 Caspase-3 Substrate VII, Fluorogenic - Calbiochem

264151
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Products

Catalogue NumberPackaging Qty/Pack
264151-1MG Plastic ampoule 1 mg
264151-5MG Plastic ampoule 5 mg
Description
OverviewFluorogenic caspase-3 substrate. Also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10.
Catalogue Number264151
Brand Family Calbiochem®
SynonymsAc-DEVD-AFC
References
ReferencesKeramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₃₀H₃₄F₃N₅O₁₃
Chemical formulaC₃₀H₃₄F₃N₅O₁₃
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetFluorogenic caspase-3 substrate
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Emission max.
Excitation max.
Peptide SequenceAc-Asp-Glu-Val-Asp-AFC
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Caspase-3 Substrate VII, Fluorogenic - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-3 Substrate VII, Fluorogenic - Calbiochem Certificates of Analysis

TitleLot Number
264151

References

Reference overview
Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure

Citations

Title
  • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision15-June-2008 RFH
    SynonymsAc-DEVD-AFC
    DescriptionFluorogenic caspase-3 substrate (excitation maximum: ~400 nm; emission maximum: ~505 nm). Also acts as a substrate for granzyme B-processed ICE-LAP3, caspase-6, caspase-7, caspase-8, and caspase-10.
    FormWhite lyophilized solid
    Chemical formulaC₃₀H₃₄F₃N₅O₁₃
    Peptide SequenceAc-Asp-Glu-Val-Asp-AFC
    Purity≥95% by HPLC
    SolubilityDMSO (5 mg/ml)
    Storage -20°C
    Protect from moisture
    Protect from light
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesKeramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
    Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
    Citation
  • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.