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233630 Cryptotanshinone - CAS 35825-57-1 - Calbiochem

233630
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₉H₂₀O₃35825-57-1

Products

Catalogue NumberPackaging Qty/Pack
233630-10MG Plastic ampoule 10 mg
Description
OverviewCryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 µM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 µM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 µM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).
Catalogue Number233630
Brand Family Calbiochem®
SynonymsAMPK Signaling Activator VIII
References
ReferencesShin, D.S., et al. 2009. Cancer Res. 69, 193.
Kim, E.J., et al. 2007. Mol. Pharmacol. 72, 62.
Product Information
CAS number35825-57-1
FormOrange solid
Hill FormulaC₁₉H₂₀O₃
Chemical formulaC₁₉H₂₀O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/37-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cryptotanshinone - CAS 35825-57-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Cryptotanshinone - CAS 35825-57-1 - Calbiochem Certificates of Analysis

TitleLot Number
233630

References

Reference overview
Shin, D.S., et al. 2009. Cancer Res. 69, 193.
Kim, E.J., et al. 2007. Mol. Pharmacol. 72, 62.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-September-2009 RFH
SynonymsAMPK Signaling Activator VIII
DescriptionCryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 µM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 µM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 µM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).
FormOrange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number35825-57-1
Chemical formulaC₁₉H₂₀O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesShin, D.S., et al. 2009. Cancer Res. 69, 193.
Kim, E.J., et al. 2007. Mol. Pharmacol. 72, 62.