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317641 Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem

317641
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₄H₂₀N₄O₂ • HCl866396-34-1

Products

Catalogue NumberPackaging Qty/Pack
317641-5MG Glass bottle 5 mg
Description
OverviewAn orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 µM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.
Catalogue Number317641
Brand Family Calbiochem®
Synonyms1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III
References
ReferencesWright, S.W., et al. 2006. J. Med. Chem. 49, 3068.
Product Information
CAS number866396-34-1
FormWhite solid
Hill FormulaC₁₄H₂₀N₄O₂ • HCl
Chemical formulaC₁₄H₂₀N₄O₂ • HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem Certificates of Analysis

TitleLot Number
317641

References

Reference overview
Wright, S.W., et al. 2006. J. Med. Chem. 49, 3068.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-November-2008 RFH
Synonyms1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III
DescriptionAn orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 µM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number866396-34-1
Chemical formulaC₁₄H₂₀N₄O₂ • HCl
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityEthanol (20 mg/ml), H₂O (20 mg/ml), or PBS (20 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesWright, S.W., et al. 2006. J. Med. Chem. 49, 3068.