Key Spec Table
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|344282-5MG||Glass bottle||5 mg|
|Overview||The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50 = 4 µM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50 = 25 µM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. The solid form of this compound (Cat. No. 344270) is also available.|
|Formulation||A 50 mM (5 mg/244 µl) solution of Forskolin, Coleus forskohlii (Cat. No. 344270) in DMSO.|
|Structure formula Image|
|Purity||≥97% by HPLC|
|Safety Information according to GHS|
|Product Usage Statements|
|Storage and Shipping Information|
|Ship Code||Dry Ice Only|
|Protect from Light||Protect from light|
|Do not freeze||Ok to freeze|
|Special Instructions||Following initial thaw, aliquot and freeze (-20°C).|
|Packaged under inert gas||Packaged under inert gas|
Forskolin, Coleus forskohlii in DMSO - Calbiochem SDS
|D'Orazio, J.A., et al. 2006. Nature 443, 340.
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Lomo, J., et al. 1995. J. Immunol. 154, 1634.
Uneyama, H., et al. 1993. J. Biol. Chem. 268, 168.
Laurenza, A., et al. 1989. Trends Pharmacol. Sci. 10, 442.
Adashi, E.Y., and Resnick, C.E. 1986. J. Cell. Biochem. 31, 217.
Seamon, K.B., and Daly, J.W. 1986. Adv. Cyclic Nucleotide Protein Phosphorylation Res. 20, 1.
Huang, R., et al. 1982. Cyclic Nucleotide Res. 8, 385.
Metzger, H., and Lindner, E. 1981. IRCS Med. Sci. Biochem. Cardiovasc. System Pharmacol. 9, 99.
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.