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371708 Gβγ Modulator II, Gallein - CAS 2103-64-2 - Calbiochem

371708
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₂₀H₁₂O₇ • 2H₂O2103-64-2

Products

Catalogue NumberPackaging Qty/Pack
371708-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable xanthene compound that binds to Gβγ with high affinity (Kd ~400 nM derived from a surface plasma resonance binding study using Gβ1γ2) and blocks Gβγ-dependent cellular activities. Reported to exhibit in vivo prophylactic efficacy against carrageenan-induced neutrophil recruitment and tissue swelling in a murine paw edema model via either intraperitoneal or oral administration.
Catalogue Number371708
Brand Family Calbiochem®
Synonyms4,5-Dihydroxyfluorescein, dihydrate, 2-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)-benzoic acid, dihydrate
References
ReferencesLehmann, D.M., et al. 2008. Mol. Pharmacol. 73, 410.
Product Information
CAS number2103-64-2
FormBurgundy solid
Hill FormulaC₂₀H₁₂O₇ • 2H₂O
Chemical formulaC₂₀H₁₂O₇ • 2H₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-37-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Gβγ Modulator II, Gallein - CAS 2103-64-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Gβγ Modulator II, Gallein - CAS 2103-64-2 - Calbiochem Certificates of Analysis

TitleLot Number
371708

References

Reference overview
Lehmann, D.M., et al. 2008. Mol. Pharmacol. 73, 410.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision02-October-2008 RFH
Synonyms4,5-Dihydroxyfluorescein, dihydrate, 2-(3,4,5-Trihydroxy-6-oxoxanthen-9-yl)-benzoic acid, dihydrate
DescriptionA cell-permeable xanthene compound that binds to Gβγ with high affinity (Kd ~400 nM derived from a surface plasma resonance binding study using Gβ1γ2) and blocks Gβγ-dependent cellular activities. Reported to exhibit in vivo prophylactic efficacy against carrageenan-induced neutrophil recruitment and tissue swelling in a murine paw edema model via either intraperitoneal or oral administration.
FormBurgundy solid
Intert gas (Yes/No) Packaged under inert gas
CAS number2103-64-2
Chemical formulaC₂₀H₁₂O₇ • 2H₂O
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLehmann, D.M., et al. 2008. Mol. Pharmacol. 73, 410.