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361554 GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem

361554
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₈H₁₄N₄O₂601514-19-6

Products

Catalogue NumberPackaging Qty/Pack
361554-1MG Plastic ampoule 1 mg
361554-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable pyrrolopyrimidine compound that acts as a potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM) and increases the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
Catalogue Number361554
Brand Family Calbiochem®
SynonymsNeurogenesis Inducer, TWS119
References
ReferencesDing, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.
Product Information
CAS number601514-19-6
ATP CompetitiveN
FormBeige solid
Hill FormulaC₁₈H₁₄N₄O₂
Chemical formulaC₁₈H₁₄N₄O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGSK-3β
Primary Target IC<sub>50</sub>30 nM; Kd = 126 nM against GSK-3β
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GSK-3β Inhibitor XII, TWS119 - CAS 601514-19-6 - Calbiochem Certificates of Analysis

TitleLot Number
361554

References

Reference overview
Ding, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsNeurogenesis Inducer, TWS119
DescriptionA cell-permeable and potent inhibitor of GSK-3β (IC50 = 30 nM). Binds to GSK-3β with high-affinity (Kd = 126 nM), leading to an increase in the level of β-catenin, a downstream substrate of GSK-3β in the Wnt signaling pathway. Shown to selectively induce neuronal differentiation in both pluripotent murine embryonal carcinoma cells (P19; 30-40% at 1 µM) and embryonic stem cells (D3; 50-60% at 400 nM).
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
CAS number601514-19-6
Chemical formulaC₁₈H₁₄N₄O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (200 mg/ml) or Methanol (2 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesDing, S., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 7632.