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400035 Glucose Transporter Inhibitor II - Calbiochem

400035
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
400035-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable thiazolidinedione compound that is shown to reversibly block glucose uptake in androgen-sensitive human prostate adenocarcinoma (LNCaP) cells transfected with GLUT1 (IC50 = 2 µM). Blocks GLUT3, GLUT4, and GLUT9-mediated transport at higher concentration (IC50 ≥ 5 µM). Binds to GLUT1 at a site that is distinct from the glucose binding site. Selectively reduces proliferation (IC50 = 2.0 µM) and induces apoptosis (IC50 = 2.5 µM) in LNCaP cells without affecting normal human prostate epithelial cells and mammary epithelial cells (~ 10 µM). Shown to elicit energy restriction-associated cellular responses in LNCaP cells, such as β-TrCP facilitated protein degradation, activation of AMP-activated kinase, and endoplasmic reticulum stress.
Catalogue Number400035
Brand Family Calbiochem®
Synonyms(Z)-5-(4-Hydroxy-3-trifluoromethyl-benzylidene)-3-(4,4,4-trifluoro-2-methyl-2-(2,2,2-trifluoroethyl)-butyl)-thiazolidine-2,4-dione
References
ReferencesWang, D-S., et al. 2012, J. Med. Chem. 55, 3827.
Product Information
FormWhite powder
Hill FormulaC₁₈H₁₄F₉NO₃S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetglucose transporter
Primary Target IC<sub>50</sub>2 µ
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Use only fresh DMSO.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Glucose Transporter Inhibitor II - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Glucose Transporter Inhibitor II - Calbiochem Certificates of Analysis

TitleLot Number
400035

References

Reference overview
Wang, D-S., et al. 2012, J. Med. Chem. 55, 3827.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-November-2012 JSW
Synonyms(Z)-5-(4-Hydroxy-3-trifluoromethyl-benzylidene)-3-(4,4,4-trifluoro-2-methyl-2-(2,2,2-trifluoroethyl)-butyl)-thiazolidine-2,4-dione
DescriptionA cell-permeable thiazolidinedione compound that is shown to reversibly block glucose uptake in androgen-sensitive human prostate adenocarcinoma (LNCaP) cells transfected with GLUT1 (IC50 = 2 µM). Blocks GLUT3, GLUT4, and GLUT9-mediated transport at higher concentration (IC50 ≥ 5 µM). Binds to GLUT1 at a site that is distinct from the glucose binding site. Selectively reduces proliferation (IC50 = 2.0 µM) and induces apoptosis (IC50 = 2.5 µM) in LNCaP cells without affecting normal human prostate epithelial cells and mammary epithelial cells (~ 10 µM). Shown to elicit energy restriction-associated cellular responses in LNCaP cells, such as β-TrCP facilitated protein degradation, activation of AMP-activated kinase, and endoplasmic reticulum stress.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Use only fresh DMSO.
Toxicity Standard Handling
ReferencesWang, D-S., et al. 2012, J. Med. Chem. 55, 3827.