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370679 Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem

370679
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Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₈H₁₄BrN₅O₆PS · Na172806-20-1

Products

Catalogue NumberPackaging Qty/Pack
370679-1UMOL Plastic ampoule 1 umol
Description
OverviewA metabolically-stable, competitive inhibitor of protein kinase G types 1α and 1β (Ki = 30 nM). Blocks cGMP-gated retinal type ion channels (IC50 = 25 µM) and the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 1 µmol = 0.56 mg.
Catalogue Number370679
Brand Family Calbiochem®
SynonymsRp-8-Br-PET-cGMPS, Na, PKG Inhibitor VI
References
ReferencesWei, J.Y., et al. 1996. Biochemistry 35, 16815.
Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.
Product Information
CAS number172806-20-1
ATP CompetitiveN
DeclarationSold under license of U.S. Patent 5,625,056, Patents DE 3,802,865.4, and DE 4,217,679 issued to BIOLOG LSI.
FormLyophilized
Hill FormulaC₁₈H₁₄BrN₅O₆PS · Na
Chemical formulaC₁₈H₁₄BrN₅O₆PS · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKG1α & 1β
Primary Target K<sub>i</sub>30 nM against PKG1α & 1β
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, β-Phenyl-1,N²-etheno-8-bromo-, Rp-Isomer, Sodium Salt - CAS 172806-20-1 - Calbiochem Certificates of Analysis

TitleLot Number
370679

References

Reference overview
Wei, J.Y., et al. 1996. Biochemistry 35, 16815.
Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-October-2007 JSW
SynonymsRp-8-Br-PET-cGMPS, Na, PKG Inhibitor VI
DescriptionA metabolically-stable, competitive inhibitor of protein kinase G type Iα and Iβ (Ki = 30 nM) that also blocks cGMP-gated retinal type ion channels (IC50 = 25 µM). Also reported to block the activation of purified PKA type II (Ki = 10 µM). More lipophilic and cell-permeable than Rp-8-pCPT-cGMPS (Cat. No. 370677). Note: 5 µmol = 2.81 mg.
FormLyophilized
CAS number172806-20-1
Chemical formulaC₁₈H₁₄BrN₅O₆PS · Na
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (5 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesWei, J.Y., et al. 1996. Biochemistry 35, 16815.
Butt, E., et al. 1995. Br. J. Pharmacol. 116, 3110.