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400083 HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem

400083
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
934593-90-5C₂₆H₂₉NO₅

Products

Catalogue NumberPackaging Qty/Pack
400083-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein. Shown to inhibit malate dehydrogenase 2 (MDH2) activity and suppress mitochondrial respiration. Also available as a 25 mM solution in DMSO (Cat. No. 400092).
Catalogue Number400083
Brand Family Calbiochem®
SynonymsCAY10585, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor, LW6
References
ReferencesLee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982.
Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
Product Information
CAS number934593-90-5
FormLight beige powder
Hill FormulaC₂₆H₂₉NO₅
Chemical formulaC₂₆H₂₉NO₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem Certificates of Analysis

TitleLot Number
400083

References

Reference overview
Lee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982.
Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-December-2013 JSW
SynonymsCAY10585, 3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor, LW6
DescriptionA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.
FormLight beige powder
Intert gas (Yes/No) Packaged under inert gas
CAS number934593-90-5
Chemical formulaC₂₆H₂₉NO₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLee, K., et al., 2013. Angew. Chem. Int. Ed. 52, In press.
Lee, K. et. al. 2010. Biochem. Pharmacol. 80, 982.
Lee, K., et al. 2007. J. Med. Chem. 50, 1675.