Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

400084 HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem

400084
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
385786-48-1C₂₁H₁₆ClN₃O₂

Products

Catalogue NumberPackaging Qty/Pack
400084-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.
Catalogue Number400084
Brand Family Calbiochem®
References
ReferencesSmirnova, N.A., et al. 2010. Chem. Biol. 4, 380.
Product Information
CAS number385786-48-1
FormTan solid
Hill FormulaC₂₁H₁₆ClN₃O₂
Chemical formulaC₂₁H₁₆ClN₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

HIF Prolyl Hydroxylase Inhibitor - CAS 385786-48-1 - Calbiochem Certificates of Analysis

TitleLot Number
400084

References

Reference overview
Smirnova, N.A., et al. 2010. Chem. Biol. 4, 380.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-February-2011 RFH
DescriptionA cell-permeable, hydroxyquinoline HIF Prolyl Hydroxylase (PHD) inhibitor that displays an IC50 = 2 µM in a cell-based assay using a reporter produced by fusing HIF-1α oxygen degradable domain (ODD) to luciferase. This compound (5 µM) is shown to significantly stabilize HIF-1α in vitro and upregulate known HIF target genes, Epo and VEGF, in SH-SY5Y human neuroblastoma cell lines. It also exerts a neuroprotective effect (IC50 = 0.25 µM in an oxidative stress model using cortical neurons.
FormTan solid
CAS number385786-48-1
Chemical formulaC₂₁H₁₆ClN₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSmirnova, N.A., et al. 2010. Chem. Biol. 4, 380.