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382148 Histone Deacetylase Inhibitor II - CAS 174664-65-4 - Calbiochem

382148
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical FormulaCAS #
C₁₀H₁₀N₂O₄174664-65-4

Products

Catalogue NumberPackaging Qty/Pack
382148-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 µM). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma.
Catalogue Number382148
Brand Family Calbiochem®
SynonymsCBHA, m-Carboxycinnamic Acid bis-Hydroxamide
References
ReferencesCoffey, D.C., et al. 2001. Cancer Res. 61, 3591.
Coffey, D.C., et al. 2000. Pediatr. Oncol. 35, 577.
Marks, P.A., et al. 2000. J. Natl. Cancer Inst. 92, 1210.
Glick, R.D., et al. 1999. Cancer Res. 59, 4392.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.
Product Information
CAS number174664-65-4
ATP CompetitiveN
DeclarationNot available for sale in the United States.
FormOff-white solid
Hill FormulaC₁₀H₁₀N₂O₄
Chemical formulaC₁₀H₁₀N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHDAC
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Histone Deacetylase Inhibitor II - CAS 174664-65-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Histone Deacetylase Inhibitor II - CAS 174664-65-4 - Calbiochem Certificates of Analysis

TitleLot Number
382148

References

Reference overview
Coffey, D.C., et al. 2001. Cancer Res. 61, 3591.
Coffey, D.C., et al. 2000. Pediatr. Oncol. 35, 577.
Marks, P.A., et al. 2000. J. Natl. Cancer Inst. 92, 1210.
Glick, R.D., et al. 1999. Cancer Res. 59, 4392.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.

Technical Info

Title
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsCBHA, m-Carboxycinnamic Acid bis-Hydroxamide
DescriptionA cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 µM). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma cells, which can be blocked by Caspase Inhibitor Z-VAD-FMK (Cat. No. 627610).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number174664-65-4
Chemical formulaC₁₀H₁₀N₂O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCoffey, D.C., et al. 2001. Cancer Res. 61, 3591.
Coffey, D.C., et al. 2000. Pediatr. Oncol. 35, 577.
Marks, P.A., et al. 2000. J. Natl. Cancer Inst. 92, 1210.
Glick, R.D., et al. 1999. Cancer Res. 59, 4392.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.