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400076 Hypericin - CAS 548-04-9 - Calbiochem

400076
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
548-04-9C₃₀H₁₆O₈

Products

Catalogue NumberPackaging Qty/Pack
400076-1MG Plastic ampoule 1 mg
Description
OverviewPolycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC50 = 3.3 μM). Also known to inhibit casein kinase II (IC50 = 6 nM), MAP kinase (IC50 = 4 nM), and the protein tyrosine activities of the insulin receptor (IC50 = 20-29 nM) and the epidermal growth factor receptor (IC50 = 35 nM).
Catalogue Number400076
Brand Family Calbiochem®
SynonymsCasein Kinase II Inhibitor XI
References
ReferencesZhang, W., et al. 1997. Cancer Lett. 120, 31.
Agostinis, P., et al. 1995. Biochem. Pharmacol. 49, 1615.
Frew, T., et al. 1994. Anticancer Res. 14, 2425.
Barnard, D.L., et al. 1992. Antiviral Res. 17, 63.
Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun. 165, 1207.
Product Information
CAS number548-04-9
ATP CompetitiveN
FormBlack solid
Hill FormulaC₃₀H₁₆O₈
Chemical formulaC₃₀H₁₆O₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>3.3 µM, 6 nM, 4 nM, 20-29 nM , 35 nM, against protein kinase C, casein kinase II, MAP kinase, the protein tyrosine activities of the insulin receptor, and the epidermal growth factor receptor, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Hypericin - CAS 548-04-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Hypericin - CAS 548-04-9 - Calbiochem Certificates of Analysis

TitleLot Number
400076

References

Reference overview
Zhang, W., et al. 1997. Cancer Lett. 120, 31.
Agostinis, P., et al. 1995. Biochem. Pharmacol. 49, 1615.
Frew, T., et al. 1994. Anticancer Res. 14, 2425.
Barnard, D.L., et al. 1992. Antiviral Res. 17, 63.
Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun. 165, 1207.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-December-2015 JSW
SynonymsCasein Kinase II Inhibitor XI
DescriptionPolycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC50 = 3.3 µM). Also known to inhibit the protein tyrosine kinase activities of the insulin receptor (IC50 = 20-29 nM), the epidermal growth factor receptor (IC50 = 35 nM), casein kinase II (IC50 = 6 nM), and MAP kinase (IC50 = 4 nM). Useful probe for PKC due to its bright red fluorescence emission and photostability. Also see Pseudohypericin (Cat. No. 539590).
FormBlack solid
CAS number548-04-9
Chemical formulaC₃₀H₁₆O₈
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml), Ethanol (1 mg/ml) or Methanol (1 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
Merck USA index14, 4863
ReferencesZhang, W., et al. 1997. Cancer Lett. 120, 31.
Agostinis, P., et al. 1995. Biochem. Pharmacol. 49, 1615.
Frew, T., et al. 1994. Anticancer Res. 14, 2425.
Barnard, D.L., et al. 1992. Antiviral Res. 17, 63.
Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun. 165, 1207.