Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

401486 IKK Inhibitor VII - CAS 873225-46-8 - Calbiochem

401486
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
873225-46-8C₂₈H₂₉N₅OS

Products

Catalogue NumberPackaging Qty/Pack
401486-1MG Glass bottle 1 mg
Description
OverviewA cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats. Also available as a 10 mM solution in DMSO (Cat. No. 505378).
Catalogue Number401486
Brand Family Calbiochem®
SynonymsIKK 16
References
ReferencesWaelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.
Product Information
CAS number873225-46-8
ATP CompetitiveY
FormPale yellow solid
Hill FormulaC₂₈H₂₉N₅OS
Chemical formulaC₂₈H₂₉N₅OS
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationIKK Inhibitor VII, CAS 873225-46-8, is a cell-permeable, potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40, 70, and 200 nM for IKK-2, IKK complex & IKK-1, respectively).
Biological Information
Primary TargetIKK
Primary Target IC<sub>50</sub>40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 22-24/25

Do not breathe dust.
Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

IKK Inhibitor VII - CAS 873225-46-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

IKK Inhibitor VII - CAS 873225-46-8 - Calbiochem Certificates of Analysis

TitleLot Number
401486

References

Reference overview
Waelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.

Brochure

Title
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsIKK 16
DescriptionA cell-permeable benzamido-pyrimidine compound that acts as a potent, selective, and ATP-competitive inhibitor of IKK (IC50 = 40 nM, 70 nM, and 200 nM for IKK-2, IKK complex, and IKK-1, respectively). Inhibits cellular IκBα degradation and NF-κB-mediated gene expression in vitro in HUVEC cells and has been shown to exhibit excellent in vivo efficacy both in mice and rats.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number873225-46-8
Chemical formulaC₂₈H₂₉N₅OS
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesWaelchli, R., et al. 2006. Bioorg. Med. Chem. Lett. 16, 108.