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407331 ILK inhibitor, Cpd 22 - Calbiochem

407331
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₀H₃₀F₃N₅O

Products

Catalogue NumberPackaging Qty/Pack
407331-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC50 = 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC50 = 1 to 2.5 µM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.
Catalogue Number407331
Brand Family Calbiochem®
References
ReferencesLee, S., et al. 2011. J. Med. Chem. 54, 6364
Product Information
FormOff-white powder
Hill FormulaC₃₀H₃₀F₃N₅O
Chemical formulaC₃₀H₃₀F₃N₅O
Quality LevelMQ100
Applications
ApplicationILK inhibitor, Cpd 22, is a cell-permeable, potent & specific inhibitor of integrin-linked kinase (ILK; IC50 = 600 nM) with anti-proliferative potency against prostrate & breast cancer cell lines.
Biological Information
Purity≥94% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

ILK inhibitor, Cpd 22 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

ILK inhibitor, Cpd 22 - Calbiochem Certificates of Analysis

TitleLot Number
407331

References

Reference overview
Lee, S., et al. 2011. J. Med. Chem. 54, 6364
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-August-2016 JSW
DescriptionA cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC50 = 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC50 = 1 to 2.5 mM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₀H₃₀F₃N₅O
Purity≥94% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLee, S., et al. 2011. J. Med. Chem. 54, 6364