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218708 InSolution™ Casein Kinase II Inhibitor I - Calbiochem

218708
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₆HBr₄N₃

Products

Catalogue NumberPackaging Qty/Pack
218708-5MG Plastic ampoule 5 mg
Description
Catalogue Number218708
Brand Family Calbiochem®
References
ReferencesBorowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
Sarno, S., et al. 2003. Biochem. J. 374, 639.
Sarno, S., et al. 2001. FEBS Lett. 496, 44.
Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.
Product Information
ATP CompetitiveY
FormLiquid
FormulationA 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO.
Hill FormulaC₆HBr₄N₃
Chemical formulaC₆HBr₄N₃
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCK2 rat liver, human recombinant
Primary Target IC<sub>50</sub>900 nM and 1.6 µM, using rat liver and human recombinant CK2, respectively
PuritySingle spot by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ Casein Kinase II Inhibitor I - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ Casein Kinase II Inhibitor I - Calbiochem Certificates of Analysis

TitleLot Number
218708

References

Reference overview
Borowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
Sarno, S., et al. 2003. Biochem. J. 374, 639.
Sarno, S., et al. 2001. FEBS Lett. 496, 44.
Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418."
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-June-2008 RFH
DescriptionA cell-permeable, highly selective, ATP/GTP-competitive casein kinase II (CKII) inhibitor (IC50 = 900 nM and 1.6 µM for rat liver and human recombinant CKII, respectively) and DYRK (IC50 <1 µM for DYRK1a). Specificity for CKII has been reported following the screening of 33 kinases, including PKA, Akt, PKC, MKK1, ERK2, p38, JNK, Lck, Lyn, and Syk. Also reported to inhibit NS3-associated viral helicase activity in hepatitis C virus (HCV) (IC50 = 20 and 60 µM using DNA and RNA substrates, respectively) and West Nile virus (WNV) (IC50 = 1.7 µM and 900 nM using DNA and RNA substrates, respectively).
FormLiquid
FormulationA 10 mM (5 mg/1.15 ml) solution of Casein Kinase II Inhibitor I (Cat. No. 218697) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₆HBr₄N₃
Structure formulaStructure formula
PuritySingle spot by TLC
Storage +2°C to +8°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
Toxicity Carcinogenic / Teratogenic
ReferencesBorowski, P., et al. 2003. Eur. J. Biochem. 270, 1645.
Zien, P., et al. 2003. Biochem. Biophys. Res. Commun. 306, 129.
Sarno, S., et al. 2003. Biochem. J. 374, 639.
Sarno, S., et al. 2001. FEBS Lett. 496, 44.
Szyszka, R., et al. 1995. Biochem. Biophys. Res. Commun. 208, 418.