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400092 InSolution™ HIF-1 Inhibitor - CAS 934593-90-5 - Calbiochem

400092
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
934593-90-5C₂₆H₂₉NO₅

Products

Catalogue NumberPackaging Qty/Pack
400092-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.
Catalogue Number400092
Brand Family Calbiochem®
Synonyms3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor
References
ReferencesNaik, R., et. al. 2012. J. Med. Chem. 55, 10564.
Lee, K., et. al. 2010. Biochem. Pharmacol. 80, 982.
Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
Product Information
CAS number934593-90-5
FormLiquid
FormulationA 25 mM (5 mg/459 µL) solution of HIF-1 Inhibitor (Cat. No. 400083) in DMSO.
Hill FormulaC₂₆H₂₉NO₅
Chemical formulaC₂₆H₂₉NO₅
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHIF-1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

References

Reference overview
Naik, R., et. al. 2012. J. Med. Chem. 55, 10564.
Lee, K., et. al. 2010. Biochem. Pharmacol. 80, 982.
Lee, K., et al. 2007. J. Med. Chem. 50, 1675.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision22-February-2013 JSW
Synonyms3-(2-(4-Adamantan-1-yl-phenoxy)-acetylamino)-4-hydroxybenzoic acid methyl ester, Hypoxia-Inducible Factor-1 Inhibitor
DescriptionA cell-permeable amidophenolic compound that inhibits hypoxia-induced HIF-1 transcription activity (IC50 = 0.7 and 2.6 µM using AGS and Hep3B cells, respectively, in a reporter assay) by selectively blocking the hypoxia-induced accumulation of cellular HIF-1α protein, while exhibiting no apparent effect on the cellular level of HIF-1α mRNA or that of HIF-1β protein.
FormLiquid
FormulationA 25 mM (5 mg/459 µL) solution of HIF-1 Inhibitor (Cat. No. 400083) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number934593-90-5
Chemical formulaC₂₆H₂₉NO₅
Structure formulaStructure formula
Purity≥95% by HPLC
Storage -20°C
Hygroscopic
Protect from light
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesNaik, R., et. al. 2012. J. Med. Chem. 55, 10564.
Lee, K., et. al. 2010. Biochem. Pharmacol. 80, 982.
Lee, K., et al. 2007. J. Med. Chem. 50, 1675.