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407602 InSolution™ Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

407602
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
509093-47-4C₂₀H₂₁N₅O₄

Products

Catalogue NumberPackaging Qty/Pack
407602-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. The solid form of this compound (Cat. No. 407601) is also available.
Catalogue Number407602
Brand Family Calbiochem®
SynonymsN-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, N-(1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide
References
ReferencesSrivastava, R., et al. 2012. Cancer Res. 72, In press.
Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.
Product Information
CAS number509093-47-4
FormLiquid
FormulationA 25 mM (5 mg/506 µL) solution of Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor (Cat. No. 407601) in DMSO.
Hill FormulaC₂₀H₂₁N₅O₄
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetIRAK-1/4
Primary Target IC<sub>50</sub>300 nM and 200 nM for IRAK-1 and -4
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

InSolution™ Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem Certificates of Analysis

TitleLot Number
407602

References

Reference overview
Srivastava, R., et al. 2012. Cancer Res. 72, In press.
Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-December-2012 JSW
SynonymsN-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, N-(1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide
DescriptionA cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. The solid form of this compound (Cat. No. 407601) is also available.
FormLiquid
FormulationA 25 mM (5 mg/506 µL) solution of Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor (Cat. No. 407601) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
CAS number509093-47-4
Structure formulaStructure formula
Purity≥98% by HPLC
Storage ≤ -70°C
Hygroscopic
Protect from light
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
Toxicity Irritant
ReferencesSrivastava, R., et al. 2012. Cancer Res. 72, In press.
Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.