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420336 KB-R7943 - CAS 182004-65-5 - Calbiochem

420336
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
182004-65-5C₁₆H₁₇N₃O₃S • MeSO₃H

Products

Catalogue NumberPackaging Qty/Pack
420336-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable isothiourea derivative that inhibits the influx/reverse mode of Na+/Ca2+ exchangers (NCX; IC50 = 4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively) and directly modulates Na+/Mg2+ exchange in a Ca2+-dependent manner. Reported to offer neuronal and cardioprotection. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC50 < 10 µM).
Catalogue Number420336
Brand Family Calbiochem®
Synonyms2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate, NMDA Antagonist III
References
ReferencesHobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.
Product Information
CAS number182004-65-5
ATP CompetitiveN
FormWhite crystalline solid
Hill FormulaC₁₆H₁₇N₃O₃S • MeSO₃H
Chemical formulaC₁₆H₁₇N₃O₃S • MeSO₃H
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNa+/Ca2+ exchangers
Primary Target IC<sub>50</sub>4.3 µM, 4.7 µM, and 1.4 µM for NCX1,NCX2, and NCX3, respectively
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

KB-R7943 - CAS 182004-65-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

KB-R7943 - CAS 182004-65-5 - Calbiochem Certificates of Analysis

TitleLot Number
420336

References

Reference overview
Hobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-July-2008 RFH
Synonyms2-(2-(4-(4-Nitrobenzyloxy)phenyl)ethyl)isothiourea, methane sulfonate, NMDA Antagonist III
DescriptionA cell-permeable inhibitor of the influx/reverse mode of the Na+/Ca2+ exchanger (NCX) (IC50 = 4.3 µM for NCX1, 4.7 µM for NCX2, and 1.4 µM for NCX3). Directly modulates Na+/Mg2+ exchange in a Ca2+-dependent manner. Reported ot offer neuronal and cardio-protection against ischemic injury. Also inhibits nicotinic acetylcholine receptors and NMDA receptor channels (IC50 <10 µM).
FormWhite crystalline solid
Intert gas (Yes/No) Packaged under inert gas
CAS number182004-65-5
Chemical formulaC₁₆H₁₇N₃O₃S • MeSO₃H
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (40 mg/ml) or H₂O (4 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesHobai, I.A., and O'Rourke, B. 2004. Expert Opin. Investig. Drugs 13, 653.
Uetani, T., et al. 2003. J. Biol. Chem. 278, 47491.
Iwamoto, T., et al. 2001. Mol. Pharmacol. 59, 524.
Pintado, A.J., et al. 2000. Br. J. Pharmacol. 130, 1893.
Sobolevsky, A.I., and Khodorov, B.I. 1999. Neuropharmacology 38, 1235.
Iwamoto, T., et al. 1996. J. Biol. Chem. 271, 22391.
Watano, T., et al. 1996. Br. J. Pharmacol. 119, 555.