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422625 KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem

422625
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
749872-43-3C₁₆H₁₈N₂O₇S

Products

Catalogue NumberPackaging Qty/Pack
422625-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50 = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182.
Catalogue Number422625
Brand Family Calbiochem®
Synonyms2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate
References
ReferencesBialkowska, A., et al. 2011. Mol. Cancer Ther. 10, 2043.
Product Information
CAS number749872-43-3
FormOff-white solid
Hill FormulaC₁₆H₁₈N₂O₇S
Chemical formulaC₁₆H₁₈N₂O₇S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

KLF5 Inhibitor, CID 5951923 - CAS 749872-43-3 - Calbiochem Certificates of Analysis

TitleLot Number
422625

References

Reference overview
Bialkowska, A., et al. 2011. Mol. Cancer Ther. 10, 2043.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-September-2013 JSW
Synonyms2-((1,1-Dioxidotetrahydrothiophen-3-yl)(methyl)amino)-2-oxoethyl-(2E)-3-(3-nitrophenyl)prop-2-enoate
DescriptionA cell-permeable phenylpropenoate compound that inhibits the proliferation of colon cancer cell lines exhibiting high levels of KLF5 (IC50 = 1.6 µM in DLD-1 cells). Downregulates the expression of early growth response protein 1 (EGR1), which modulates KLF5 expression at transcription level. Shown to activate the EGFR/ERK pathway by stimulating phosphorylation of EGFR-Tyr1068 and ERK1/2-Thr202/Tyr204. Also, up-regulates the phosphorylation of p38 MAPK-Thr180/Tyr182.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number749872-43-3
Chemical formulaC₁₆H₁₈N₂O₇S
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock Solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBialkowska, A., et al. 2011. Mol. Cancer Ther. 10, 2043.