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422720 L-744,832 - CAS 1177806-11-9 - Calbiochem

422720
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1177806-11-9C₂₆H₄₅N₃O₆S₂ · 2HCl

Products

Catalogue NumberPackaging Qty/Pack
422720-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable potent and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor with anti-tumor properties. Rapidly blocks p70S6K activation and DNA synthesis and promotes apoptosis in transgenic mice. Induces p21 expression and cell cycle arrest in the G1 phase. Displays synergistic effect with paclitaxel and epothilones in inhibiting tumor growth. Also mimics many of the effects of Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropriate activation of the mTOR/p70S6K pathway.
Catalogue Number422720
Brand Family Calbiochem®
Synonyms(2S)-2-[[(2S)-2-[(2S,3S)-2-[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylpentyl]oxy]-1-oxo-3-phenylpropyl]amino]-4-(methylsulfonyl)-butanoic Acid 1-Methylethyl Ester, L-744,382
References
ReferencesLaw, B.K., et al. 2000. J. Biol. Chem. 275, 10796.
Law, B.K., et al. 1999. J. Biol. Chem. 274, 4743.
Barrington, R.E., et al. 1998. Mol. Cell. Biol. 18, 85.
Moasser, M.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1369.
Sepp-Lorenzino, L., and Rosen, N. 1998. J. Biol. Chem. 273, 20243.
Kohl, N.E., et al. 1995. Nat. Med. 1, 792.
Sepp-Lorenzino, L., et al. 1995. Cancer Res. 55, 5302.
Product Information
CAS number1177806-11-9
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₆H₄₅N₃O₆S₂ · 2HCl
Chemical formulaC₂₆H₄₅N₃O₆S₂ · 2HCl
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetFarnesyltransferase (FTase)
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

L-744,832 - CAS 1177806-11-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

L-744,832 - CAS 1177806-11-9 - Calbiochem Certificates of Analysis

TitleLot Number
422720

References

Reference overview
Law, B.K., et al. 2000. J. Biol. Chem. 275, 10796.
Law, B.K., et al. 1999. J. Biol. Chem. 274, 4743.
Barrington, R.E., et al. 1998. Mol. Cell. Biol. 18, 85.
Moasser, M.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1369.
Sepp-Lorenzino, L., and Rosen, N. 1998. J. Biol. Chem. 273, 20243.
Kohl, N.E., et al. 1995. Nat. Med. 1, 792.
Sepp-Lorenzino, L., et al. 1995. Cancer Res. 55, 5302.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-December-2018 JSW
Synonyms(2S)-2-[[(2S)-2-[(2S,3S)-2-[(2R)-2-Amino-3-mercaptopropyl]amino]-3-methylpentyl]oxy]-1-oxo-3-phenylpropyl]amino]-4-(methylsulfonyl)-butanoic Acid 1-Methylethyl Ester, L-744,382
DescriptionA potent, cell-permeable, and selective thiol-containing peptidomimetic farnesyltransferase (FTase) inhibitor that blocks p70s6k activation and DNA synthesis and promote apoptosis in transgenic mice. Induces p21 expression and arrests cell in the G1 phase of the cell cycle. Also shown to act synergistically with paclitaxel and epothilones in inhibiting tumor growth and arresting cells in metaphase. Also mimics a number of the effects exhibited by Rapamycin (Cat. No. 553210) and may be effective against tumors that exhibit inappropirate activation of the mTOR/p70s6k pathway in animal models.
FormWhite solid
CAS number1177806-11-9
Chemical formulaC₂₆H₄₅N₃O₆S₂ · 2HCl
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (25 mg/ml) or H₂O (15 mg/ml)
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLaw, B.K., et al. 2000. J. Biol. Chem. 275, 10796.
Law, B.K., et al. 1999. J. Biol. Chem. 274, 4743.
Barrington, R.E., et al. 1998. Mol. Cell. Biol. 18, 85.
Moasser, M.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 1369.
Sepp-Lorenzino, L., and Rosen, N. 1998. J. Biol. Chem. 273, 20243.
Kohl, N.E., et al. 1995. Nat. Med. 1, 792.
Sepp-Lorenzino, L., et al. 1995. Cancer Res. 55, 5302.