Key Spec Table
|CAS #||Empirical Formula|
An invalid quantity was specified. The product quantity has been adjusted.
|475848-2GM||Glass bottle||2 gm|
|Overview||A symmetrical bis-(amino, hydroxynaphthalenedisulfonate) compound that antagonizes macrophage migration inhibitory factor against receptor binding (IC50 = 810 nM against hMIF and CD74 interaction) and is more potent than ISO-1 (Cat. No. 475837) in suppressing MIF-induced cytokines and MMP-3 productions in human fibroblasts cultures (IC50 = ≤0.7 µM vs >5 µM). Unlike MIF Antagonists I-IV, p425 targets an area at the interface of two MIF trimers, distal to the active site.|
|References||Bai, F., et al. 2012. J. Biol. Chem. 287, 30653.|
|Structure formula Image|
|Purity||≥95% by HPLC|
|Safety Information according to GHS|
|R Phrase||R: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed.
|S Phrase||S: 26-36
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
|Product Usage Statements|
|Packaged under inert gas||Packaged under inert gas|
MIF Antagonist V, p425 - CAS 259444 - Calbiochem SDS
|Bai, F., et al. 2012. J. Biol. Chem. 287, 30653.|
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.