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444291 MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem

444291
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
1258003-93-8C₁₉H₂₀N₂O₇S

Products

Catalogue NumberPackaging Qty/Pack
444291-5MG 5 mg
Description
OverviewA dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC50 = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC50 = 160, 320 and 22.3 nM , respectively) or human MMP-3/13/14 (IC50 = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC50 >5 µM), TACE (IC50 >25 µM), and MMP-1/7 (IC50 >6 µM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).
Catalogue Number444291
Brand Family Calbiochem®
Synonyms(S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid
References
ReferencesLi, W., et al. 2009. J. Med. Chem. 52, 1799.
Product Information
CAS number1258003-93-8
FormOff-white solid
Hill FormulaC₁₉H₂₀N₂O₇S
Chemical formulaC₁₉H₂₀N₂O₇S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥94% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem Certificates of Analysis

TitleLot Number
444291

References

Reference overview
Li, W., et al. 2009. J. Med. Chem. 52, 1799.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-April-2011 RFH
Synonyms(S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid
DescriptionA dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC50 = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC50 = 160, 320 and 22.3 nM, respectively) or human MMP-3/13/14 (IC50 = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC50 >5 µM), TACE (IC50 >25 µM), and MMP-1/7 (IC50 >6 µM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1258003-93-8
Chemical formulaC₁₉H₂₀N₂O₇S
Structure formulaStructure formula
Purity≥94% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLi, W., et al. 2009. J. Med. Chem. 52, 1799.