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444294 MMP-2 Inhibitor IV - Calbiochem

444294
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₃H₁₄ClNO₈P₂S

Products

Catalogue NumberPackaging Qty/Pack
444294-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC50 = 37 nM), with good selectivity over MMP-8 (320 nM), MMP-9 (> 1 µM), and MMP-14 (> 1 µM). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC50 = 1.7 µM), which is more potent compared with other bisphosphonates such as Alendronate (Cat. No. 126855), (IC50 = 30 µM), and Zolendronate (7.8 µM), without observable cytotoxicity in HepG2 cells. At 25 µM, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts.
Catalogue Number444294
Brand Family Calbiochem®
SynonymsBone Resorption Inhibitor, (4'-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid
References
ReferencesRubino, M.T., et al. 2011. Chem. Med. Chem. 6, 1258.
Product Information
FormOff-white powder
Hill FormulaC₁₃H₁₄ClNO₈P₂S
Chemical formulaC₁₃H₁₄ClNO₈P₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

MMP-2 Inhibitor IV - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MMP-2 Inhibitor IV - Calbiochem Certificates of Analysis

TitleLot Number
444294

References

Reference overview
Rubino, M.T., et al. 2011. Chem. Med. Chem. 6, 1258.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-July-2012 JSW
SynonymsBone Resorption Inhibitor, (4'-chlorobiphenyl-4-ylsulfonamido)methylenediphosphonic acid
DescriptionA cell-permeable, bisphosphonate derivative that displays nanomolar activity against MMP-2 (IC50 = 37 nM), with good selectivity over MMP-8 (320 nM), MMP-9 (> 1 µM), and MMP-14 (> 1 µM). It is shown to inhibit osteoclast activity in a macrophage cell line, J774 (IC50 = 1.7 µM), which is more potent compared with other bisphosphonates such as Alendronate (Cat. No. 126855), (IC50 = 30 µM), and Zolendronate (7.8 µM), without observable cytotoxicity in HepG2 cells. At 25 µM, it abolishes the formation of actin rings, which are functional structures that are typical of resorbing osteoclasts, at activity levels comparable with those of zolendronic acid, inhibits bone resportion in vitro, and demonstrates cytotoxic properties in murine osteoclasts.
FormOff-white powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₃H₁₄ClNO₈P₂S
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (100 mg/ml; clear, colorless solution)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesRubino, M.T., et al. 2011. Chem. Med. Chem. 6, 1258.