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444284 MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem

444284
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
199850-67-4C₁₇H₁₈BrNO₄S

Products

Catalogue NumberPackaging Qty/Pack
444284-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
Catalogue Number444284
Brand Family Calbiochem®
Synonyms(S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
References
ReferencesPaolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506.
Zhou, Y.P., et al. 2005. Diabetes 54, 2612.
Peterson, J.T., et al. 2001. Circulation 103, 2303.
Spinale, F.G., et al. 1999. Circ. Res. 85, 364.
Product Information
CAS number199850-67-4
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₇H₁₈BrNO₄S
Chemical formulaC₁₇H₁₈BrNO₄S
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMMP-2, -3, and -13
Primary Target IC<sub>50</sub>47, 12, and 8 nM, against MMP-2, -3, and -13, respectively
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem Certificates of Analysis

TitleLot Number
444284

References

Reference overview
Paolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506.
Zhou, Y.P., et al. 2005. Diabetes 54, 2612.
Peterson, J.T., et al. 2001. Circulation 103, 2303.
Spinale, F.G., et al. 1999. Circ. Res. 85, 364.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-August-2008 RFH
Synonyms(S)-2-(4ʹ-Bromo-biphenyl-4-sulfonylamino-3-methylbutyric acid)
DescriptionA cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 µM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 µM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.
FormOff-white solid
CAS number199850-67-4
Chemical formulaC₁₇H₁₈BrNO₄S
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (40 mg/ml) or Ethanol (40 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesPaolocci, N., et al. 2006. J. Pharm. Exp. Ther. 317, 506.
Zhou, Y.P., et al. 2005. Diabetes 54, 2612.
Peterson, J.T., et al. 2001. Circulation 103, 2303.
Spinale, F.G., et al. 1999. Circ. Res. 85, 364.