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444290 MMP Inhibitor V - CAS 223472-31-9 - Calbiochem

444290
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
223472-31-9C₂₂H₂₈N₂O₆

Products

Catalogue NumberPackaging Qty/Pack
444290-2MG Plastic ampoule 2 mg
Description
OverviewAn orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2, -3, -8, -9, -12, -13 (Ki = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC50 = 1.6 µM), MMP-7 (Ki = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
Catalogue Number444290
Brand Family Calbiochem®
Synonyms(2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817
References
ReferencesOkamoto, Y., et al. 2007. Int. Heart J. 48, 369.
Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
Yamada, A., et al. 2000. Inflamm. Res. 49, 144.
Product Information
CAS number223472-31-9
FormOff-white solid
Hill FormulaC₂₂H₂₈N₂O₆
Chemical formulaC₂₂H₂₈N₂O₆
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

MMP Inhibitor V - CAS 223472-31-9 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MMP Inhibitor V - CAS 223472-31-9 - Calbiochem Certificates of Analysis

TitleLot Number
444290

References

Reference overview
Okamoto, Y., et al. 2007. Int. Heart J. 48, 369.
Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
Yamada, A., et al. 2000. Inflamm. Res. 49, 144.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-April-2009 RFH
Synonyms(2S,4S)-N-Hydroxy-5-ethoxymethyloxy-2-methyl-4-(4-phenoxybenzoyl)aminopentanamide, ONO-4817
DescriptionAn orally active non-peptidyl hydroxamate compound that acts as an effective broad-spectrum inhibitor against MMP-2/3/8/9/12/13 (Ki = 0.73, 42, 1.1, 2.1, 0.45, and 1.1 nM, respectively), but not MMP-1 (IC50 = 1.6 µM), MMP-7 (Ki = 2.5 µM), or other serine proteases (no activity against chymotrypsin or plasmin at 100 µM). Widely used in studying MMP-mediated diseases development in vivo. Also reported to block P-LAP secretase activity (≥70% inhibition of P-LAP shedding at 10 µM) that is otherwise not inhibited by TIMP-1/2 in CHO cell cultures in vitro.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number223472-31-9
Chemical formulaC₂₂H₂₈N₂O₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (30 mg/ml) or Ethanol (15 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesOkamoto, Y., et al. 2007. Int. Heart J. 48, 369.
Ito, N., et al. 2004. Biochem. Biophys. Res. Commun. 314, 1008.
Shiraga, M., et al. 2002. Cancer Res. 62, 5967.
Mori, T., et al. 2001. Exp. Biol. Med. 226, 429.
Yamada, A., et al. 2000. Inflamm. Res. 49, 144.