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454862 MNK1/2 Inhibitor II, ETP-45835 - Calbiochem

454862
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₃H₁₆N₄•2HCl

Products

Catalogue NumberPackaging Qty/Pack
454862-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC50 = 646 and 575 nM, respectively, against MNK1 and MNK2) with much reduced or little activity against 24 other kinases (≤15% inhibition at 5 µM). Reported to exhibit good aqueous solubility (> 100 µM at pH 7.4) and inhibit the proliferation (IC50 = 17 µM) and cellular eIF4E Ser209 phosphorylation (IC50 = 4.7 µM) of MV4:11 cells.
Catalogue Number454862
Brand Family Calbiochem®
Synonyms4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl, ETP45835, MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II
References
ReferencesOyarzabal, J., et al. 2010. J. Med. Chem. 53, 6618.
Product Information
FormWhite solid
Hill FormulaC₁₃H₁₆N₄•2HCl
Chemical formulaC₁₃H₁₆N₄•2HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

MNK1/2 Inhibitor II, ETP-45835 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MNK1/2 Inhibitor II, ETP-45835 - Calbiochem Certificates of Analysis

TitleLot Number
454862

References

Reference overview
Oyarzabal, J., et al. 2010. J. Med. Chem. 53, 6618.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision29-September-2012 JSW
Synonyms4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl, ETP45835, MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II
DescriptionA cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC50 = 646 and 575 nM, respectively, against MNK1 and MNK2) with much reduced or little activity against a panel of 24 other kinases (≤15% inhibition at 5 µM), including MNK upstream kinases B-Raf, ERK1, MEK1, and p38α. Reported to exhibit good aqueous solubility (> 100 µM at pH 7.4) and inhibit the proliferation (IC50 = 17 µM) and cellular eIF4E Ser209 phosphorylation (IC50 = 4.7 µM) of acute myeloid leukemia MV4:11 cells.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₃H₁₆N₄•2HCl
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (50 mg/ml)
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesOyarzabal, J., et al. 2010. J. Med. Chem. 53, 6618.