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444295 MT1-MMP Inhibitor, NSC405020 - Calbiochem

444295
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₂H₁₅Cl₂NO

Products

Catalogue NumberPackaging Qty/Pack
444295-25MG Glass bottle 25 mg
Description
OverviewA cell-permeable pentanylbenzamide compound that acts as an allosteric, reversible, and selective inhibitor of the collgenolytic activity of MT1-MMP. Does not affect the catalytic activity of cellular MT-1-MMP thus allows it to retain its ability to activate MMP-2. Selectively targets the hemopexin (PEX) domain of MT1-MMP, thereby repressing its pro-tumorigenic activity. Its binding to the PEX domain is dependent on Met-328, Arg-330, Asp-376, Met-422, and Ser-470 in the druggable pocket of the enzyme. Shown to block 184B5-MT cell migration on collagen-1 and repress MCF7-β3/MT tumor growth in xenografted mice (0.5 mg/kg, intratumoral).
Catalogue Number444295
Brand Family Calbiochem®
Synonyms3,4-Dichloro-N-(pentan-2-yl)benzamide, 3,4-Dichloro-N-(1-methylbutyl)benzamide
References
ReferencesRemacle, A.G., et al. 2012. Cancer Res. 72, 2339.
Product Information
FormOff-white solid
Hill FormulaC₁₂H₁₅Cl₂NO
Chemical formulaC₁₂H₁₅Cl₂NO
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

MT1-MMP Inhibitor, NSC405020 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MT1-MMP Inhibitor, NSC405020 - Calbiochem Certificates of Analysis

TitleLot Number
444295

References

Reference overview
Remacle, A.G., et al. 2012. Cancer Res. 72, 2339.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision10-August-2012 JSW
Synonyms3,4-Dichloro-N-(pentan-2-yl)benzamide, 3,4-Dichloro-N-(1-methylbutyl)benzamide
DescriptionA cell-permeable pentanylbenzamide compound that acts as an allosteric, reversible, and selective inhibitor of the collgenolytic activity of MT1-MMP. Does not affect the catalytic activity of cellular MT-1-MMP thus allows it to retain its ability to activate MMP-2. Selectively targets the hemopexin (PEX) domain of MT1-MMP, thereby repressing its pro-tumorigenic activity. Its binding to the PEX domain is dependent on Met-328, Arg-330, Asp-376, Met-422, and Ser-470 in the druggable pocket of the enzyme. Shown to block 184B5-MT cell migration on collagen-1 and repress MCF7-β3/MT tumor growth in xenografted mice (0.5 mg/kg, intratumoral).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₂H₁₅Cl₂NO
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
Toxicity Standard Handling
ReferencesRemacle, A.G., et al. 2012. Cancer Res. 72, 2339.