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454126 Methotrexate - CAS 59-05-2 - Calbiochem

454126
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
59-05-2C₂₀H₂₂N₈O₅ • 3H₂O

Products

Catalogue NumberPackaging Qty/Pack
454126-100MG Glass bottle 100 mg
Description
OverviewInhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor, and has a significant toxicity profile including hepatotoxicity, pneumonitis, and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an antitumor agent.
Catalogue Number454126
Brand Family Calbiochem®
References
ReferencesKaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
Takasuga, A., et al. 1992. J. Biochem. 112, 652.
Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065.
Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.
Product Information
CAS number59-05-2
FormYellow solid
Hill FormulaC₂₀H₂₂N₈O₅ • 3H₂O
Chemical formulaC₂₀H₂₂N₈O₅ • 3H₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 23/24/25-36/37/38-45-46

Toxic by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
May cause cancer.
May cause heritable genetic damage.
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Methotrexate - CAS 59-05-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Methotrexate - CAS 59-05-2 - Calbiochem Certificates of Analysis

TitleLot Number
454126

References

Reference overview
Kaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
Takasuga, A., et al. 1992. J. Biochem. 112, 652.
Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065.
Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-October-2010 RFH
DescriptionInhibits thymidylate synthetase, is a nonselective de novo purine synthesis inhibitor and has a significant toxicity profile including hepatotoxicity, pneumonitis and bone marrow suppression. Potent folic acid antagonist. Induces apoptosis in HL-60 human leukemia cells. Also useful as an anti-tumor agent.
FormYellow solid
CAS number59-05-2
Chemical formulaC₂₀H₂₂N₈O₅ • 3H₂O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Toxic
Merck USA index14, 5985
ReferencesKaufman, S.H., et al. 1993. Cancer Res. 53, 3976.
Takasuga, A., et al. 1992. J. Biochem. 112, 652.
Hirata, S., et al. 1989. Arthritis Rheum. 32, 1065.
Jolivet, J., et al. 1983. New Engl. J. Med. 309, 1094.