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475856 Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem

475856
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
338967-87-6C₁₅H₁₀Cl₂N₂O₂S

Products

Catalogue NumberPackaging Qty/Pack
475856-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC50 = 10 and 50 µM in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50 < 10 µM) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- (Cat. Nos. 569396 and 569397) as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release.
Catalogue Number475856
Brand Family Calbiochem®
Synonyms3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one, Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor
References
ReferencesCassidy-Stone A., et al. 2008. Dev. Cell 14, 193.
Product Information
CAS number338967-87-6
FormWhite solid
Hill FormulaC₁₅H₁₀Cl₂N₂O₂S
Chemical formulaC₁₅H₁₀Cl₂N₂O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Mitochondrial Division Inhibitor, mdivi-1 - CAS 338967-87-6 - Calbiochem Certificates of Analysis

TitleLot Number
475856

References

Reference overview
Cassidy-Stone A., et al. 2008. Dev. Cell 14, 193.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms3-(2,4-Dichloro-5-methoxy-phenyl)-2-thioxo-1H-quinazolin-4-one, Mitochondrial Division Dnm1/Drp1 ATPase Inhibitor
DescriptionA cell-permeable quinazolinone compound that inhibits yeast (Dnm1) and mammalian (Drp1) division DRPs (dynamin-related GTPases) and effectively induces mitochondrial fusion into net-like structures (IC50 = 10 and 50 µM in yeast and COS cultures, respectively) in a reversible manner. Cell-free studies indicate that mdivi-1 blocks Dnm1 ATPase activity (IC50 <10 µM) and self-assembly by an allosteric modulation-based mechanism. Mdivi-1 is shown to effectively suppress STS- (Cat. Nos. 569396 & 569397) as well as C8-Bid-induced MOMP (Mitochondrial Outer Membrane Permeabilization) in HeLa cultures and in cell-free murine liver mitochondria preparations, respectively, as assessed by cytochrome C release.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number338967-87-6
Chemical formulaC₁₅H₁₀Cl₂N₂O₂S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesCassidy-Stone A., et al. 2008. Dev. Cell 14, 193.