Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

475870 MnTBAP - Calbiochem

475870
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
55266-18-7C₄₈H₂₈ClMnN₄O₈

Products

Catalogue NumberPackaging Qty/Pack
475870-25MG Plastic ampoule 25 mg
Description
OverviewCell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of Dihydrorhodamine 123 (Cat. No. 309825) by peroxynitrite, but does not scavenge nitric oxide (NO).
Catalogue Number475870
Brand Family Calbiochem®
SynonymsMn(III)tetrakis(4-benzoic acid)porphyrin Chloride
References
ReferencesAladag, M. A., et al. 2003. Acta Neurochir. 145, 673.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
Product Information
CAS number55266-18-7
ATP CompetitiveN
FormBrown solid
Hill FormulaC₄₈H₂₈ClMnN₄O₈
Chemical formulaC₄₈H₂₈ClMnN₄O₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationMnTBAP, CAS 55266-18-7, is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger.
Biological Information
Primary TargetSuperoxide dismutase (SOD) mimetic
Primary Target IC<sub>50</sub>EC50 ~40 µM in protecting endothelial cells against paraquat (2 mM)
Purity≥95% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

MnTBAP - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MnTBAP - Calbiochem Certificates of Analysis

TitleLot Number
475870

References

Reference overview
Aladag, M. A., et al. 2003. Acta Neurochir. 145, 673.
Szabo, C., et al. 1996. FEBS Lett. 381, 82.
Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.

Brochure

Title
Pathways and Biomarkers of Oxidative Stress

Citations

Title
  • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
  • Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision11-August-2008 RFH
    SynonymsMn(III)tetrakis(4-benzoic acid)porphyrin Chloride
    DescriptionCell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger. Protects endothelial cells in a dose-dependent manner (EC50 ~40 µM) against paraquat (2 mM). Inhibits the oxidation of dihydrorhodamine-123 by peroxynitrite, but does not scavenge nitric oxide (NO).
    FormBrown solid
    CAS number55266-18-7
    Chemical formulaC₄₈H₂₈ClMnN₄O₈
    Structure formulaStructure formula
    Purity≥95% by TLC
    SolubilityAqueous alkaline solution
    Storage -20°C
    Protect from moisture
    Protect from light
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesAladag, M. A., et al. 2003. Acta Neurochir. 145, 673.
    Szabo, C., et al. 1996. FEBS Lett. 381, 82.
    Day, B.J., et al. 1995. J. Pharmacol. Exp. Ther. 275, 1227.
    Faulkner, K.M., et al. 1994. J. Biol. Chem. 269, 23471.
    Citation
  • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.