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475944 Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem

475944
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
5351-17-7C₇H₉N₃O

Products

Catalogue NumberPackaging Qty/Pack
475944-1GM Plastic ampoule 1 gm
Description
OverviewA benzoic acid hydrazide analog that acts as a potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC50 = 300 nM). Does not inhibit catalase or glutathione peroxidase activities. Does not affect the production of superoxide by neutrophils. Shown to inhibit H2O2-induced apoptosis in HL-60, human leukemia cells.
Catalogue Number475944
Brand Family Calbiochem®
References
ReferencesEngelmann, I., et al. 2000. Redox Report 5, 207.
Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
Kettle, A.J., et al. 1995. Biochem. J. 308, 559.
Product Information
CAS number5351-17-7
ATP CompetitiveN
FormWhite to beige powder
Hill FormulaC₇H₉N₃O
Chemical formulaC₇H₉N₃O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMyeloperoxidase
Primary Target IC<sub>50</sub>300 nM against myeloperoxidase (MPO)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSDG2580000
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem Certificates of Analysis

TitleLot Number
475944

References

Reference overview
Engelmann, I., et al. 2000. Redox Report 5, 207.
Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
Kettle, A.J., et al. 1995. Biochem. J. 308, 559.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-August-2020 JSW
DescriptionA benzoic acid hydrazide analog that acts as a potent, specific, and irreversible inhibitor of myeloperoxidase. ABAH is a mechanism-based inhibitor that is oxidized to radical intermediates that, in turn, promote the irreversible inactivation of myeloperoxidase. Reported to inhibit hypochlorous acid (HOCl) production by purified myeloperoxidase (IC50 = 300 nM). Has also been shown to inhibit HOCl production up to 90% in zymosan and phorbol myristate acetate stimulated neutrophils (IC50 = 16 µM and 2.2 µM, respectively). Does not affect superoxide radical production or degranulation of neutrophils and does not inhibit catalase or glutathione peroxidase. Shown to inhibit myeloperoxidase-mediated apoptosis in >90% of ras-expressing fibroblasts and glutathione-depleted, src-transformed cells. Also shown to inhibit apoptosis in H2O2-treated HL-60 promyelocytic leukemia cells.
FormWhite to beige powder
Intert gas (Yes/No) Packaged under inert gas
CAS number5351-17-7
RTECSDG2580000
Chemical formulaC₇H₉N₃O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) and dilute acids
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesEngelmann, I., et al. 2000. Redox Report 5, 207.
Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461.
Burner, U., et al. 1999. J. Biol. Chem. 274, 9494.
Kettle, A.J., et al. 1997. Biochem. J. 321, 503.
Kettle, A.J., et al. 1995. Biochem. J. 308, 559.