Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

481406 NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem

481406
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
545380-34-5C₂₂H₂₀N₄O

Products

Catalogue NumberPackaging Qty/Pack
481406-1MG Plastic Bag(s) 1 mg
Description
OverviewA cell-permeable quinazoline compound that acts as a highly potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Shown to exhibit anti-inflammatory effect on carrageenin-induced paw edema in rat. A 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481407) in DMSO is also available.
Catalogue Number481406
Brand Family Calbiochem®
Synonyms6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
References
ReferencesTobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
Product Information
CAS number545380-34-5
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₂H₂₀N₄O
Chemical formulaC₂₂H₂₀N₄O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetNF-κB transcriptional activation
Primary Target IC<sub>50</sub>11 nM against NF-κB transcriptional activation in Jurkat cells
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem Certificates of Analysis

TitleLot Number
481406

References

Reference overview
Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-October-2007 JSW
Synonyms6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
DescriptionA cell-permeable quinazoline compound that acts as a potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Does not exhibit cellular cytotoxicity even at concentrations as high as 10 µM. Reported to exhibit anti-inflammatory effects on carregeenin-induced paw edema in rats.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number545380-34-5
Chemical formulaC₂₂H₂₀N₄O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Toxic
ReferencesTobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.