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481408 NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem

481408
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
749886-87-1C₁₆H₂₀N₂

Products

Catalogue NumberPackaging Qty/Pack
481408-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC50 = 7.1 µM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.
Catalogue Number481408
Brand Family Calbiochem®
Synonyms4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
References
ReferencesShin, H.M., et al. 2004. FEBS Lett. 571, 50.
Product Information
CAS number749886-87-1
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₆H₂₀N₂
Chemical formulaC₁₆H₂₀N₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationNF-kB Activation Inhibitor II, JSH-23, CAS 749886-87-1, is a cell-permeable, selective inhibitor of nuclear translocation of NF-kB p65 and its transcription activity (IC50 = 7.1 µM).
Biological Information
Primary TargetBlocks nuclear translocation of NF-κB p65 and its transcription activity
Primary Target IC<sub>50</sub>7.1 µM in a NF-κB reporter assay using RAW 264.7
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NF-κB Activation Inhibitor II, JSH-23 - CAS 749886-87-1 - Calbiochem Certificates of Analysis

TitleLot Number
481408

References

Reference overview
Shin, H.M., et al. 2004. FEBS Lett. 571, 50.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
DescriptionA cell-permeable, selective blocker of the nuclear translocation of NF-κB p65 that does not affect IκB degradation (IC50 = 7.1 µM in LPS-stimulated macrophages RAW 264.7 stably transfected with pNF-κB-SEAP-NPT). Shown to suppress DNA-binding of NF-κB and downregulate LPS-inducible expression of TNF-α, IL-1β, IL-6, iNOS, and COX-2. Also prevents LPS-induced apoptotic chromatin condensation.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number749886-87-1
Chemical formulaC₁₆H₂₀N₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesShin, H.M., et al. 2004. FEBS Lett. 571, 50.