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480457 NF-κB Activation Inhibitor VII, CID-2858522 - Calbiochem

480457
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₈H₃₉N₃O₃

Products

Catalogue NumberPackaging Qty/Pack
480457-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable selective inhibitor of NF-κB activation induced by PKC pathway activators such as PMA (IC50 = 70 nM) in a HEK293 cell-based NF-κB luciferase reporter gene assay, by operating downstream of PKC but upstream of IKKβ, without inhibiting other NF-κB activation pathways. At 10 µM, this compound only inhibits Raf, TLK1, and JAK2 by 57%, 70%, and 53%, respectively, among a panel of 353 protein kinases. In addition, it attenuates CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T-cells (IC50 < 5 µM) and anti-IgM-stimulated proliferation of murine B-lymphocytes (IC50 = 2 µM).
Catalogue Number480457
Brand Family Calbiochem®
Synonyms1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone; CID-2858522; 2-aminobenzimidazole; Compound 1a
References
ReferencesPeddibhotla, S., et al. 2010. J. Med. Chem. 53, 4793.
Product Information
FormOff-white powder
Hill FormulaC₂₈H₃₉N₃O₃
Chemical formulaC₂₈H₃₉N₃O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity>95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

NF-κB Activation Inhibitor VII, CID-2858522 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NF-κB Activation Inhibitor VII, CID-2858522 - Calbiochem Certificates of Analysis

TitleLot Number
480457

References

Reference overview
Peddibhotla, S., et al. 2010. J. Med. Chem. 53, 4793.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-February-2011 RFH
Synonyms1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone; CID-2858522; 2-aminobenzimidazole; Compound 1a
DescriptionA cell-permeable selective inhibitor of NF-κB activation induced by PKC pathway activators such as PMA (IC50 = 70 nM) in a HEK293 cell-based NF-κB luciferase reporter gene assay, by operating downstream of PKC but upstream of IKKβ, without inhibiting other NF-κB activation pathways. At 10 µM, this compound only inhibits Raf, TLK1, and JAK2 by 57%, 70%, and 53%, respectively, among a panel of 353 protein kinases. In addition, it attenuates CD3/CD28 and PMA/ionomycin-induced production of IL-2 by Jurkat T-cells (IC50 <5 µM) and anti-IgM-stimulated proliferation of murine B-lymphocytes (IC50 = 2 µM).
FormOff-white powder
Chemical formulaC₂₈H₃₉N₃O₃
Structure formulaStructure formula
Purity>95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPeddibhotla, S., et al. 2010. J. Med. Chem. 53, 4793.