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480743 Neuronal Differentiation Inducer III - CAS 832115-62-5 - Calbiochem

480743
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
832115-62-5C₁₁H₁₀N₂O₂S

Products

Catalogue NumberPackaging Qty/Pack
480743-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells. Induces insulin expression, and activates ERK signaling and histone acetylation in MIN6 pancreatic β cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type chanenels-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.
Catalogue Number480743
Brand Family Calbiochem®
SynonymsN-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide, Isx
References
ReferencesDioum, E.M., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 20713.
Zhang, L., et al. 2011. Differentiation 81, 233.
Sadek, H., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 6063.
Schneider, J.W., et al. 2008. Nat. Chem. Biol. 4, 408.
Product Information
CAS number832115-62-5
FormOff-white solid
Hill FormulaC₁₁H₁₀N₂O₂S
Chemical formulaC₁₁H₁₀N₂O₂S
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Neuronal Differentiation Inducer III - CAS 832115-62-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Neuronal Differentiation Inducer III - CAS 832115-62-5 - Calbiochem Certificates of Analysis

TitleLot Number
480743

References

Reference overview
Dioum, E.M., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 20713.
Zhang, L., et al. 2011. Differentiation 81, 233.
Sadek, H., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 6063.
Schneider, J.W., et al. 2008. Nat. Chem. Biol. 4, 408.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-June-2013 JSW
SynonymsN-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide, Isx
DescriptionA cell-permeable isoxazole compound that selectively induces robust neuronal differentiation (Effective concentration = 20 µM) in various stem/progenitor cells. Induces insulin expression, and activates ERK signaling and histone acetylation in MIN6 pancreatic β cells. The underlying excitation-neurogenesis signaling is comprised of, at least in part, an initial NMDA receptor- and L-type chanenels-mediated Ca2+ influx, followed by an activation of CaMKII, phosphorylation/nuclear export of the MEF2 repressor HDAC5, the subsequent de-repression of MEF2, and the eventual activation of the HDAC-MEF2 epigenetic/transcriptional regulatory network.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number832115-62-5
Chemical formulaC₁₁H₁₀N₂O₂S
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml) or Ethanol (3 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDioum, E.M., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 20713.
Zhang, L., et al. 2011. Differentiation 81, 233.
Sadek, H., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 6063.
Schneider, J.W., et al. 2008. Nat. Chem. Biol. 4, 408.