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480746 Neuronal Differentiation Inducer IV - Calbiochem

480746
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₈H₁₇N₃O₃

Products

Catalogue NumberPackaging Qty/Pack
480746-5MG Glass bottle 5 mg
Description
OverviewA cell-permeable quinoxaline compound that is shown to induce neuronal differentiation in PC12 and rat MSC (mesenchymal stem cell) cultures with high efficiency (> 95%; 20 µM for 48 h) as determined by Nissl staining, expressions of neuronal markers and genes (β-III tubulin, NSE, Chrna2, Chrnb2, Chrm4, Foxo2, Sizn 1), as well as by whole-cell electrophysiology measurements, without any concomitant astroglial differentiation induction as indicated by the absence of GFAP (glial fibrillary acidic protein) expression.
Catalogue Number480746
Brand Family Calbiochem®
SynonymsN-Hydroxy-2-oxo-3-(3-phenylpropyl)-1,2-dihydroquinoxaline-6-carboxamide, 2-Oxo-3-(3-phenyl-propyl)-1,2-dihydro-quinoxaline-6-carboxylic acid hydroxyamide
References
ReferencesKim, N.R., et al. 2009. J. Med. Chem. 52, 7931.
Product Information
FormOff-white solid
Hill FormulaC₁₈H₁₇N₃O₃
Chemical formulaC₁₈H₁₇N₃O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Neuronal Differentiation Inducer IV - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Neuronal Differentiation Inducer IV - Calbiochem Certificates of Analysis

TitleLot Number
480746

References

Reference overview
Kim, N.R., et al. 2009. J. Med. Chem. 52, 7931.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-June-2012 JSW
SynonymsN-Hydroxy-2-oxo-3-(3-phenylpropyl)-1,2-dihydroquinoxaline-6-carboxamide, 2-Oxo-3-(3-phenyl-propyl)-1,2-dihydro-quinoxaline-6-carboxylic acid hydroxyamide
DescriptionA cell-permeable quinoxaline compound that is shown to induce neuronal differentiation in PC12 and rat MSC (mesenchymal stem cell) cultures with high efficiency (> 95%; 20 µM for 48 h) as determined by Nissl staining, expressions of neuronal markers and genes (β-III tubulin, NSE, Chrna2, Chrnb2, Chrm4, Foxo2, Sizn 1), as well as by whole-cell electrophysiology measurements, without any concomitant astroglial differentiation induction as indicated by the absence of GFAP (glial fibrillary acidic protein) expression.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₁₇N₃O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml; pale yellow solution)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKim, N.R., et al. 2009. J. Med. Chem. 52, 7931.