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475957 c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem

475957
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
413611-93-5C₁₈H₁₂N₄O₃

Products

Catalogue NumberPackaging Qty/Pack
475957-10MG 10 mg
Description
OverviewA cell-permeable benzoxadiazole compound that is shown to preferentially disrupt the interactions of c-Myc-Max, Mad1-Max, and Myf5-HEB, over those of 31 other pairs of HLH-, ZIP-, and HLH-ZIP-containing proteins. Similarly to 10058-F4 (Cat. No. 475956), 10074-G5 is shown to selectively inhibit the c-Myc-dependent growth of rat fibroblast cell line TGR1 and effectively suppress c-Myc-dependent transcription activity. Binding studies using various mutated and truncated c-Myc constructs reveal that 10074-G5 targets c-Myc helix-1 region between aa residues 363 and 381 (KD = 4.4 µM), while 10058-F4 interaction site is located within aa residues 402 through 412 (KD = 13 µM).
Catalogue Number475957
Brand Family Calbiochem®
Synonyms7-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine, Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-ylamine, 10074-G5
References
ReferencesFollis, A.V., et al. 2008. Chem. Biol. 15, 1149.
Yin, X., et al. 2003. Oncogene 22, 6151.

Sold under license of U.S. Patent 7,026,343.
Product Information
CAS number413611-93-5
FormDeep orange solid
Hill FormulaC₁₈H₁₂N₄O₃
Chemical formulaC₁₈H₁₂N₄O₃
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

c-Myc Inhibitor II - CAS 413611-93-5 - Calbiochem Certificates of Analysis

TitleLot Number
475957

References

Reference overview
Follis, A.V., et al. 2008. Chem. Biol. 15, 1149.
Yin, X., et al. 2003. Oncogene 22, 6151.

Sold under license of U.S. Patent 7,026,343.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-December-2010 RFH
Synonyms7-Nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine, Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-ylamine, 10074-G5
DescriptionA cell-permeable benzoxadiazole compound that is shown to preferentially disrupt the interactions of c-Myc-Max, Mad1-Max, and Myf5-HEB, over those of 31 other pairs of HLH-, ZIP-, and HLH-ZIP-containing proteins. Similarly to 10058-F4 (Cat. No. 475956), 10074-G5 is shown to selectively inhibit the c-Myc-dependent growth of rat fibroblast cell line TGR1 and effectively suppress c-Myc-dependent transcription activity. Binding studies using various mutated and truncated c-Myc constructs reveal that 10074-G5 targets c-Myc helix-1 region between aa 363 and 381 (KD = 4.4 µM), while 10058-F4 interaction site is located within aa residues 402 through 412 (KD = 13 µM).
FormDeep orange solid
Intert gas (Yes/No) Packaged under inert gas
CAS number413611-93-5
Chemical formulaC₁₈H₁₂N₄O₃
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesFollis, A.V., et al. 2008. Chem. Biol. 15, 1149.
Yin, X., et al. 2003. Oncogene 22, 6151.

Sold under license of U.S. Patent 7,026,343.