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445865 mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem

445865
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
781652-57-1C₂₃H₁₆N₄O

Products

Catalogue NumberPackaging Qty/Pack
445865-1MG Plastic ampoule 1 mg
Description
OverviewA pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic glutamate receptor subtype 5 (mGluR5). Also exerts anti-psychotic-like effects. Reported to potentiate the response to glutamate (~300 nM) in CHO-mGluR5 cells (EC50 = 10 nM for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation) and reverse amphetamine-induced disruption of pre-pulse inhibition (PPI) in rats. Specificity was determined using a panel of kinases and receptors. Does not potentiate the activity of other glutamate receptors.
Catalogue Number445865
Brand Family Calbiochem®
Synonyms3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
References
ReferencesKinney, G.G., et al. 2005. J. Pharmacol. Exp. Ther. 313, 199.
Lindsley, C.W., et al. 2004. J. Med. Chem. 47, 5825.
Product Information
CAS number781652-57-1
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₃H₁₆N₄O
Chemical formulaC₂₃H₁₆N₄O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMetabotropic glutamate receptor subtype 5 (mGluR5)
Primary Target IC<sub>50</sub>EC50 = 10 nM in potentiating the response to glutamate (~300 nM) in CHO-mGluR5 cells for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation
Purity≥99% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

mGluR5 Ligand, CDPPB - CAS 781652-57-1 - Calbiochem Certificates of Analysis

TitleLot Number
445865

References

Reference overview
Kinney, G.G., et al. 2005. J. Pharmacol. Exp. Ther. 313, 199.
Lindsley, C.W., et al. 2004. J. Med. Chem. 47, 5825.

Brochure

Title
Pathways and Biomarkers of Glutamatergic Synapse Flyer
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide
DescriptionA pyrazole amide compound that crosses the blood-brain barrier and acts as a potent, selective, reversible, positive allosteric modulator for metabotropic glutamate receptor subtype 5 (mGluR5). Also exerts anti-psychotic-like effects. Reported to potentiate the response to glutamate (~300 nM) in CHO-mGluR5 cells (EC50 = 10 nM for human, 4-fold potentiation; 20 nM for rat, 4.3-fold potentiation) and reverse amphetamine-induced disruption of pre-pulse inhibition (PPI) in rats. Specificity was determined using a panel of kinases and receptors. Does not potentiate the activity of other glutamate receptors.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number781652-57-1
Chemical formulaC₂₃H₁₆N₄O
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKinney, G.G., et al. 2005. J. Pharmacol. Exp. Ther. 313, 199.
Lindsley, C.W., et al. 2004. J. Med. Chem. 47, 5825.