Once the virus clearance step has been optimized and virus retention studies completed, your next challenge is designing a strategy that enables you to increase your flow volumes within the constraints of your physical plant, without violating the safety margins you have established for your project.
A key decision is finding a filter configuration that will support a large-scale implementation. When multiple filters are required to process the batch volume you have set, look for a filtration solution that can be installed to meet your process time requirements and to meet the physical constraints of your plant. Merck can help increase your probability of success with Procedural reviews, Operator Training, Equipment Qualification and our knowledge in standard approaches and expertise in downstream processing.