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119150 Adenosine A2A Receptor Antagonist II, SCH-58261 - CAS 160098-96-4 - Calbiochem

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Synonymes: 2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, SCH58261, SCH 58261

119150
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119150-10MG
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      Description
      OverviewA highly potent and selective antagonist of adenosine A2A receptor (Ki = 600 pM). Does not affect the activity of other adenosine receptors in any significant manner (Ki = 287 nM; 5.0 µM, and > 10 µM for A1, A2B, and A3 receptors, respectively). Displays neuroprotective effects in cerebral ischaemia in rats, and shown to counteract Parkinsonian-like muscle rigidity in rats.
      Catalogue Number119150
      Brand Family Calbiochem®
      Synonyms2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, SCH58261, SCH 58261
      References
      ReferencesOngini, E., et al. 1999. Naunyn Schmiedebergs Arch. Pharmacol. 359, 7.
      Monopoli, A., et al. 1998. Neuroport. 9, 3955.
      Zocchi, C., et al. 1996. J. Pharmacol. Exp. Ther. 276, 398.
      Popoli, P., et al. 2000. Neuropsychopharmacology. 22, 522.
      Product Information
      CAS number160098-96-4
      FormOff-white solid
      Hill FormulaC₁₈H₁₅N₇O
      Chemical formulaC₁₈H₁₅N₇O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetA2A Receptor
      Primary Target K<sub>i</sub>600 pM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Adenosine A2A Receptor Antagonist II, SCH-58261 - CAS 160098-96-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      119150

      Références bibliographiques

      Aperçu de la référence bibliographique
      Ongini, E., et al. 1999. Naunyn Schmiedebergs Arch. Pharmacol. 359, 7.
      Monopoli, A., et al. 1998. Neuroport. 9, 3955.
      Zocchi, C., et al. 1996. J. Pharmacol. Exp. Ther. 276, 398.
      Popoli, P., et al. 2000. Neuropsychopharmacology. 22, 522.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-May-2013 JSW
      Synonyms2-(furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, SCH58261, SCH 58261
      DescriptionA highly potent and selective antagonist of adenosine A2A receptor (Ki = 600 pM). Does not affect the activity of other adenosine receptors in any significant manner (Ki = 287 nM; 5.0 µM, and > 10 µM for A1, A2B, and A3 receptors, respectively). Displays neuroprotective effects in cerebral ischaemia in rats, and shown to counteract Parkinsonian-like muscle rigidity in rats.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number160098-96-4
      Chemical formulaC₁₈H₁₅N₇O
      Structure formulaStructure formula
      Purity≥99% by HPLC
      Solubility100 mM in DMSO
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesOngini, E., et al. 1999. Naunyn Schmiedebergs Arch. Pharmacol. 359, 7.
      Monopoli, A., et al. 1998. Neuroport. 9, 3955.
      Zocchi, C., et al. 1996. J. Pharmacol. Exp. Ther. 276, 398.
      Popoli, P., et al. 2000. Neuropsychopharmacology. 22, 522.