164640 Aminopurvalanol A - CAS 220792-57-4 - Calbiochem

A cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97

Primary Target: Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35
164640
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₁₉H₂₆ClN₇O 220792-57-4

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      164640-5MG
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      Disponibilité limitéeDisponibilité limitée
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      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
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          Nous vous tiendrons informé
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          		 Ampoule plast. 5 mg
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          Description
          OverviewA cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 = ~ 1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~ 100-fold greater selectivity over a panel of kinases tested (IC50 ≥ 2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
          Catalogue Number164640
          Brand Family Calbiochem®
          Synonyms(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
          References
          ReferencesBreton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
          Knockaert, M., et al. 2002.Oncogene 21, 6413.
          Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
          Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
          Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
          Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.
          Product Information
          CAS number220792-57-4
          ATP CompetitiveY
          DeclarationSold under license of U.S. Patent 6,255,485 and 6,617,331.
          FormPale yellow solid
          Hill FormulaC₁₉H₂₆ClN₇O
          Chemical formulaC₁₉H₂₆ClN₇O
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35
          Primary Target IC<sub>50</sub>33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Aminopurvalanol A - CAS 220792-57-4 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Aminopurvalanol A - CAS 220792-57-4 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          164640

          Références bibliographiques

          Aperçu de la référence bibliographique
          Breton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
          Knockaert, M., et al. 2002.Oncogene 21, 6413.
          Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
          Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
          Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
          Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-April-2008 RFH
          Synonyms(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
          DescriptionA cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 ~1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~100-fold greater selectivity over a panel of kinases tested (IC50 ≥2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
          FormPale yellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number220792-57-4
          Chemical formulaC₁₉H₂₆ClN₇O
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (40 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesBreton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
          Knockaert, M., et al. 2002.Oncogene 21, 6413.
          Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
          Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
          Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
          Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.