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164640 Aminopurvalanol A - CAS 220792-57-4 - Calbiochem

A cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97

Primary Target: Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35
164640
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
220792-57-4C₁₉H₂₆ClN₇O

Prix & Disponibilité

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164640-5MG
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      Description
      OverviewA cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 = ~ 1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~ 100-fold greater selectivity over a panel of kinases tested (IC50 ≥ 2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
      Catalogue Number164640
      Brand Family Calbiochem®
      Synonyms(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
      References
      ReferencesBreton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
      Knockaert, M., et al. 2002.Oncogene 21, 6413.
      Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
      Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
      Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
      Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.
      Product Information
      CAS number220792-57-4
      ATP CompetitiveY
      DeclarationSold under license of U.S. Patent 6,255,485 and 6,617,331.
      FormPale yellow solid
      Hill FormulaC₁₉H₂₆ClN₇O
      Chemical formulaC₁₉H₂₆ClN₇O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, and Cdk5/p35
      Primary Target IC<sub>50</sub>33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Aminopurvalanol A - CAS 220792-57-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Aminopurvalanol A - CAS 220792-57-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      164640

      Références bibliographiques

      Aperçu de la référence bibliographique
      Breton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
      Knockaert, M., et al. 2002.Oncogene 21, 6413.
      Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
      Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
      Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
      Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-April-2008 RFH
      Synonyms(2R)-2-((6-((3-Amino-5-chlorophenyl)amino)-9-(1-methylethyl)-9H-purin-2-yl)amino)-3-methyl-1-butanol, NG-97
      DescriptionA cell-permeable 2,6,9-trisubstituted purine analog that displays anti-mitotic as well as anti-tumor properties (GI50 ~1.8 µM in the NCI 60-cell panel in vitro activity screen; potently inhibits the growth of KM12 colon cancer cells with a GI50 of 30 nM). Acts as a reversible and ATP-competitive inhibitor of Cdks (IC50 = 33 nM for Cdk1/cyclin B and Cdk2/cyclin A, 28 nM for Cdk2/cyclin E, and 20 nM for Cdk5/p35), and displays ~100-fold greater selectivity over a panel of kinases tested (IC50 ≥2.4 µM). Shown to induce cell differentiation by preferentially targeting the G2/M-phase and act intracellularly by inhibiting both Cdks and MAPKs.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number220792-57-4
      Chemical formulaC₁₉H₂₆ClN₇O
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (40 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Irritant
      ReferencesBreton, M.L., et al. 2003. Biochem. Biophys. Res. Commun. 306, 880.
      Knockaert, M., et al. 2002.Oncogene 21, 6413.
      Adachi, S., et al. 2001. Mol. Cell. Biol. 21, 4929.
      Knockaert, M., et al. 2000. Chem. Biol. 7, 411.
      Rosiana, G.R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 4797.
      Chang, Y.T., et al. 1999. Chem. Biol. 6, 361.