505308 CDDO-Me - CAS 218600-53-4 - Calbiochem

505308
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
Demander le prix
Disponibilité limitéeDisponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service
      Voir les Prix & la Disponibilité

      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical FormulaCAS #
      C₃₂H₄₃NO₄ 218600-53-4

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      5053080001
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          Flacon en verre 10 mg
          Prix en cours de récupération
          Le prix n'a pas pu être récupéré
          La quantité minimale doit être un multiple de
          À la validation de la commande Plus d'informations
          Vous avez sauvegardé ()
           
          Demander le prix
          Description
          OverviewA cell-permeable, bioavailable synthetic oleanane triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. Shown to significantly reduce the expression of several inflammatory mediators, including IL-6, IL-10, IL-12, TNFα, Mip1α and others. Reverses high fat diet-induced type 2 diabetes in C57BL/6 mice (3 mg/kg) and improves glucose homeostasis and insulin sensitivity. Down-regulates lipogenic gene expression in hepatocytes. Exhibits anti-proliferative activity in osteosarcoma cells (IC50 = 800, 150, 330, and 170 nM in HOB-c, KHOS, KHOSR2, and U2OS cells, respectively). Enhances the effectiveness of chemotherapeutic agents by inducing intrinsic mitochondrial-dependent apoptotic pathway. Reported to interact with multi cellular targets, namely, Nrf2-Keap1, IKK, JAK-STAT, PPARγ, ErbB2, PTEN, mTOR and Arp3 and covalently modify active site Cys residue via Michael addition.
          Catalogue Number505308
          Brand Family Calbiochem®
          SynonymsMethyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate, Bardoxolone methyl, BARD, NSC 713200, Nrf Activator V
          References
          ReferencesLiby, K.T. and Sporn, M.B., 2012. Pharmacol. Rev. 64, 972.
          Saha, P.K. et al. 2010. J. Biol. Chem. 285, 40581.
          Ryu, K., et al. 2010. BMC Cancer 10, 187.
          Liby, K.T., et al. 2007. Nat. Rev. Cancer 7, 357.
          Shishodia S., et al. 2006. Clin. Cancer Res. 12, 1828.
          Zou, W., et al. 2004. Cancer Res. 64, 7570.
          Kim, Y., et al. 2002. J. Biol. Chem. 277, 22320.
          Konopleva, M., et al. 2002. Blood 99, 326.
          Wang, Y., et al. 2000. Mol Endocrinol. 14, 1550.
          Product Information
          CAS number218600-53-4
          FormWhite solid
          Hill FormulaC₃₂H₄₃NO₄
          Chemical formulaC₃₂H₄₃NO₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          CDDO-Me - CAS 218600-53-4 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Références bibliographiques

          Aperçu de la référence bibliographique
          Liby, K.T. and Sporn, M.B., 2012. Pharmacol. Rev. 64, 972.
          Saha, P.K. et al. 2010. J. Biol. Chem. 285, 40581.
          Ryu, K., et al. 2010. BMC Cancer 10, 187.
          Liby, K.T., et al. 2007. Nat. Rev. Cancer 7, 357.
          Shishodia S., et al. 2006. Clin. Cancer Res. 12, 1828.
          Zou, W., et al. 2004. Cancer Res. 64, 7570.
          Kim, Y., et al. 2002. J. Biol. Chem. 277, 22320.
          Konopleva, M., et al. 2002. Blood 99, 326.
          Wang, Y., et al. 2000. Mol Endocrinol. 14, 1550.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-July-2013 JSW
          SynonymsMethyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate, Bardoxolone methyl, BARD, NSC 713200, Nrf Activator V
          DescriptionA cell-permeable, bioavailable synthetic oleanane triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. Shown to significantly reduce the expression of several inflammatory mediators, including IL-6, IL-10, IL-12, TNFα, Mip1α and others. Reverses high fat diet-induced type 2 diabetes in C57BL/6 mice (3 mg/kg) and improves glucose homeostasis and insulin sensitivity. Down-regulates lipogenic gene expression in hepatocytes. Exhibits anti-proliferative activity in osteosarcoma cells (IC50 = 800, 150, 330, and 170 nM in HOB-c, KHOS, KHOSR2, and U2OS cells, respectively). Enhances the effectiveness of chemotherapeutic agents by inducing intrinsic mitochondrial-dependent apoptotic pathway. Reported to interact with multi cellular targets, namely, Nrf2-Keap1, IKK, JAK-STAT, PPARγ, ErbB2, PTEN, mTOR and Arp3 and covalently modify active site Cys residue via Michael addition.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number218600-53-4
          Chemical formulaC₃₂H₄₃NO₄
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml). Use only fresh DMSO for reconstitution.
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesLiby, K.T. and Sporn, M.B., 2012. Pharmacol. Rev. 64, 972.
          Saha, P.K. et al. 2010. J. Biol. Chem. 285, 40581.
          Ryu, K., et al. 2010. BMC Cancer 10, 187.
          Liby, K.T., et al. 2007. Nat. Rev. Cancer 7, 357.
          Shishodia S., et al. 2006. Clin. Cancer Res. 12, 1828.
          Zou, W., et al. 2004. Cancer Res. 64, 7570.
          Kim, Y., et al. 2002. J. Biol. Chem. 277, 22320.
          Konopleva, M., et al. 2002. Blood 99, 326.
          Wang, Y., et al. 2000. Mol Endocrinol. 14, 1550.