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205536 Cadein1 - Calbiochem

A cell-permeable isoquinolinium compound that preferentially induces apoptotic cell death in p53-deficient cancer cells with functional MMR (DNA mismatch repair) system.

Cadein1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 1-Pentadecyl-6,7-dimethoxy-2-(2,6-difluorobenzyl)-3,4-dihydroisoquinolium chloride, Cancer-selective death inducer 1

205536
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Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₃₃H₄₈F₂INO₂

Prix & Disponibilité

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205536-10MG
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      Description
      OverviewA cell-permeable isoquinolinium compound that preferentially induces apoptotic cell death in p53-deficient cancer cells with functional MMR (DNA mismatch repair) system, including HCT116-Ch3/E6, HeLa, HT29, and SW620 (viability <19 %; 4-6 µM Cadein1 for 24 h), while exhibiting much reduced potency in MMR-/p53+ (RKO and HCT116), MMR-/p53- (DLD-1 and HCT116-E6), and MMR+/p53+ (HCT116-Ch3 and HEK293) cancer cultures (viability = 40 to 92%; 4 µM Cadein1 for 24 h).
      Catalogue Number205536
      Brand Family Calbiochem®
      Synonyms1-Pentadecyl-6,7-dimethoxy-2-(2,6-difluorobenzyl)-3,4-dihydroisoquinolium chloride, Cancer-selective death inducer 1
      References
      ReferencesJang, E.R., et al. 2010. J. Biol. Chem. 285, 2986.
      Product Information
      FormYellow powder
      Hill FormulaC₃₃H₄₈F₂INO₂
      Chemical formulaC₃₃H₄₈F₂INO₂
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cadein1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Cadein1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      205536

      Références bibliographiques

      Aperçu de la référence bibliographique
      Jang, E.R., et al. 2010. J. Biol. Chem. 285, 2986.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-October-2012 JSW
      Synonyms1-Pentadecyl-6,7-dimethoxy-2-(2,6-difluorobenzyl)-3,4-dihydroisoquinolium chloride, Cancer-selective death inducer 1
      DescriptionA cell-permeable isoquinolinium compound that preferentially induces p38 phosphorylation, caspase-3 activation, PARP cleavage, and apoptotic cell death in p53-deficient cancer cells with functional MMR (DNA mismatch repair) system, including HCT116-Ch3/E6, HT29, SW620 (viability = 10.6, 32, and 18.6%, respectively; 4 µM Cadein1 for 24 h), and HeLa (17.7% viability; 6 µM Cadein1 for 24 h), while exhibiting much reduced potency toward MMR-/p53+ (80% and 68.6% viability of RKO and HCT116, respectively; 4 µM Cadein1 for 24 h), MMR-/p53- (51% and 49% viability of DLD-1 and HCT116-E6, respectively; 4 µM Cadein1 for 24 h), or MMR+/p53+ (55.4% and 92% viability of HCT116-Ch3 and HEK293, respectively; 4 µM Cadein1 for 24 h) cancer cells. MMR function knockdown in MMR+/p53- SW620 cells confers Cadein1 resistance (70% viability; 4 µM Cadein1 for 24 h), likewise p53 downregulation in MMR+/p53+ HEK293 cells restores sensitivity to Cadein1 (45% viability; 4 µM Cadein1 for 24 h).
      FormYellow powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₃H₄₈F₂INO₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Hygroscopic
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesJang, E.R., et al. 2010. J. Biol. Chem. 285, 2986.