218833 Caspase-6 Inhibitor XII, pep419 - Calbiochem

The Caspase-6 Inhibitor XII, pep419 controls the biological activity of Caspase-6. This small molecule/inhibitor is primarily used for Cancer applications.

Caspase-6 Inhibitor XII, pep419 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Caspase inhibitor, pep419

218833
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₉₉H₁₆₂N₃₀O₂₉S

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      218833-5MG
      Récupération des données relatives à la disponibilité...
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      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          		 Flacon en verre 5 mg
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          Description
          OverviewAn 18-mer synthetic peptide that acts as a selective, non-competitive inhibitor of caspase-6 (IC50 = 8.6 µM). Blocks the activity of processed caspase-6 as evidenced by its reduced ability to process VEID-AMC substrate. Exhibits only a trivial effect on caspase-9 and 7 and does not affect the activities of caspases 1, 2, 3, 4, 5, 8, and 10. Acts as an allosteric peptide ligand that binds outside the active site of the enzyme and impairs its activity. Pep419 is shown to bind as a dimer to an allosteric site of caspase-6 zymogen resulting in its tetramerizaton and stabilization. Its binding site is shown to be distinct from the substrate binding site of the enzyme. Electroporation has been shown to enable the entry of 5-carboxyfluorescein-labeled peptide into SKNAS bone marrow neuroblastoma cells.
          Catalogue Number218833
          Brand Family Calbiochem®
          SynonymsCaspase inhibitor, pep419
          References
          ReferencesStanger, K., et al. 2012. Nat. Chem. Bio. 8, 655.
          Product Information
          FormWhite powder
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₉₉H₁₆₂N₃₀O₂₉S
          Chemical formulaC₉₉H₁₆₂N₃₀O₂₉S
          Quality LevelMQ100
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Peptide SequenceAc-TEKEKGRLHCVEWTILER-NH2
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Caspase-6 Inhibitor XII, pep419 - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Caspase-6 Inhibitor XII, pep419 - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          218833

          Références bibliographiques

          Aperçu de la référence bibliographique
          Stanger, K., et al. 2012. Nat. Chem. Bio. 8, 655.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-June-2013 JSW
          SynonymsCaspase inhibitor, pep419
          DescriptionAn 18-mer synthetic peptide that acts as a selective, non-competitive inhibitor of caspase-6 (IC50 = 8.6 µM). Blocks the activity of processed caspase-6 as evidenced by its reduced ability to process VEID-AMC substrate. Exhibits only a trivial effect on caspase-9 and 7 and does not affect the activities of caspases 1, 2, 3, 4, 5, 8, and 10. Acts as an allosteric peptide ligand that binds outside the active site of the enzyme and impairs its activity. Pep419 is shown to bind as a dimer to an allosteric site of caspase-6 zymogen resulting in its tetramerizaton and stabilization. Its binding site is shown to be distinct from the substrate binding site of the enzyme. Electroporation has been shown to enable the entry of 5-carboxyfluorescein-labeled peptide into SKNAS bone marrow neuroblastoma cells.
          FormWhite powder
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₉₉H₁₆₂N₃₀O₂₉S
          Peptide SequenceAc-TEKEKGRLHCVEWTILER-NH2
          Purity≥95% by HPLC
          SolubilityH₂O (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesStanger, K., et al. 2012. Nat. Chem. Bio. 8, 655.