234397 Complement C5a, His·Tag®, Human, Recombinant, E. coli

234397
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      Replacement Information

      Prix & Disponibilité

      Référence DisponibilitéConditionnement Qté Prix Quantité
      234397-100UG
      Récupération des données relatives à la disponibilité...
      Disponibilité limitéeDisponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
        Pour le restant : Nous vous tiendrons informé
          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
          Contacter le Service Clients
          Contact Customer Service

          Ampoule plast. 100 μg
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          Description
          OverviewRecombinant, human C5a complement (74 amino acids) fused at the N-terminus to a His•Tag® sequence and a proprietary vector sequence necessary for expression and expressed in E. coli. The recombinant protein is not further processed to remove the additional sequence. Activation of complement by either pathway results in the formation of C5-cleaving enzymes (C5 convertases) on target surfaces. The C5 convertase enzymes cleave the C5 α-chain at peptide bond 74 resulting in the production and release of the C5a glycopeptide. C5a is the most biologically active of the three complement-derived anaphylatoxins. C5a expresses a wide variety of biogical activities which include: inflammatory cell chemotaxis, smooth muscle contraction, and release reactions of neutrophils, mast cells, and macrophages.


          Available in Bulk - request a quote!
          Catalogue Number234397
          Brand Family Calbiochem®
          References
          ReferencesCarney, D.F. and Hugli, T.E. 1993. Protein Sci. 2, 1391.
          Hugli, T.E., et al. 1981. Mol. Cell. Biochem. 41, 59.
          Product Information
          FormLyophilized solid
          Quality LevelMQ100
          Applications
          Biological Information
          Biological activityExhibits equal activity to that of serum-derived C5a based on a myeloperoxidase release assay.
          Purity≥95% by SDS-PAGE
          Physicochemical Information
          ContaminantsEndotoxins: ≤0.1 ng/µg protein
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          Complement C5a, His·Tag®, Human, Recombinant, E. coli Certificats d'analyse

          TitreNuméro de lot
          234397

          Références bibliographiques

          Aperçu de la référence bibliographique
          Carney, D.F. and Hugli, T.E. 1993. Protein Sci. 2, 1391.
          Hugli, T.E., et al. 1981. Mol. Cell. Biochem. 41, 59.
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-May-2009 JSW
          DescriptionRecombinant, human C5 a complement (74 amino acids) fused at the N-terminus to a His•Tag® sequence and a proprietary vector sequence necessary for expression and expressed in E. coli. The recombinant protein is not further processed to remove the additional sequences. Activation of complement by either pathway results in the formation of C5-cleaving enzymes (C5 convertase) on target surfaces. The C5 convertase enzymes cleave the C5a chain at peptide bond 74, resulting in the production and release of the C5a glycopeptide. C5a is the most biologically active of the three complement-derived anaphylatoxins. C5a exhibits a wide variety of biological activities, including inflammatory cell chemotaxis, smooth muscle contraction, and degranulation of neutrophils, mast cells, and macrophages.
          FormLyophilized solid
          Purity≥95% by SDS-PAGE
          ContaminantsEndotoxins: ≤0.1 ng/µg protein
          Biological activityExhibits equal activity to that of serum-derived C5a based on a myeloperoxidase release assay.
          SolubilityReconstitute in sterile H₂O containing 2.5 mg/ml BSA.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C.
          Toxicity Standard Handling
          ReferencesCarney, D.F. and Hugli, T.E. 1993. Protein Sci. 2, 1391.
          Hugli, T.E., et al. 1981. Mol. Cell. Biochem. 41, 59.